RECRUITING

GI Oxalate Absorption

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week. For the first two days, subjects will be asked to eat a special diet at home. From Days 3-5, they will eat special meals delivered to their home from a research clinic at the University of Chicago. They will also collect 24-hour urine samples at home on Days 4 and 5. On Day 6, they will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. They will receive a special liquid that contains oxalate, and we will have them eat a specially prepared breakfast that is low in oxalate and citrate.

Official Title

Determine the Contribution of Paracellular GI Oxalate Absorption in Obese and Roux-en-Y Gastric Bypass Kidney Stone Patients

Quick Facts

Study Start:2023-01-25
Study Completion:2026-08-02
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05356000

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-70
  2. * Previous history of Roux-en-Y gastric bypass
  3. * History of at least one calcium-based kidney stone after surgery
  4. * Pre-protocol urine oxalate above the lab normal range (50mg/day)
  5. * Age 18-70
  6. * Body mass index (BMI) \>=30kg/m2
  7. * History of at least one calcium-based kidney stone
  8. * Pre-protocol urine oxalate above the lab normal range (50mg/day)
  9. * Age 18-70, BMI between 18.5-29.9 kg/m2
  10. * History of at least one calcium-based kidney stone
  1. * History of colon resection (partial or complete)
  2. * History of duodenal switch bowel surgery
  3. * History of ileal-jejunal bypass surgery
  4. * History of primarily uric acid, cysteine, or struvite stones
  5. * History of bowel surgery
  6. * History of colon resection
  7. * History of inflammatory bowel disease (Crohn's disease, Ulcerative Colitis)
  8. * History of primarily uric acid, cysteine, or struvite stones

Contacts and Locations

Study Contact

Megan Prochaska, MD
CONTACT
773-702-1000
mprocha2@medicine.bsd.uchicago.edu
Elaine Worcester, MD
CONTACT
773-702-3630
eworcest@medicine.bsd.uchicago.edu

Study Locations (Sites)

University of Chicago Medical Center
Chicago, Illinois, 60637
United States

Collaborators and Investigators

Sponsor: University of Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-01-25
Study Completion Date2026-08-02

Study Record Updates

Study Start Date2023-01-25
Study Completion Date2026-08-02

Terms related to this study

Keywords Provided by Researchers

  • Roux-en-Y Gastric Bypass
  • RYGB
  • Oxalate

Additional Relevant MeSH Terms

  • Bariatric Surgery Candidate
  • Kidney Stone