GI Oxalate Absorption

Description

This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week. For the first two days, subjects will be asked to eat a special diet at home. From Days 3-5, they will eat special meals delivered to their home from a research clinic at the University of Chicago. They will also collect 24-hour urine samples at home on Days 4 and 5. On Day 6, they will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. They will receive a special liquid that contains oxalate, and we will have them eat a specially prepared breakfast that is low in oxalate and citrate.

Conditions

Bariatric Surgery Candidate, Kidney Stone

Study Overview

Study Details

Study overview

This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week. For the first two days, subjects will be asked to eat a special diet at home. From Days 3-5, they will eat special meals delivered to their home from a research clinic at the University of Chicago. They will also collect 24-hour urine samples at home on Days 4 and 5. On Day 6, they will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. They will receive a special liquid that contains oxalate, and we will have them eat a specially prepared breakfast that is low in oxalate and citrate.

Determine the Contribution of Paracellular GI Oxalate Absorption in Obese and Roux-en-Y Gastric Bypass Kidney Stone Patients

GI Oxalate Absorption

Condition
Bariatric Surgery Candidate
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Chicago Medical Center, Chicago, Illinois, United States, 60637

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-70
  • * Previous history of Roux-en-Y gastric bypass
  • * History of at least one calcium-based kidney stone after surgery
  • * Pre-protocol urine oxalate above the lab normal range (50mg/day)
  • * Age 18-70
  • * Body mass index (BMI) \>=30kg/m2
  • * History of at least one calcium-based kidney stone
  • * Pre-protocol urine oxalate above the lab normal range (50mg/day)
  • * Age 18-70, BMI between 18.5-29.9 kg/m2
  • * History of at least one calcium-based kidney stone
  • * History of colon resection (partial or complete)
  • * History of duodenal switch bowel surgery
  • * History of ileal-jejunal bypass surgery
  • * History of primarily uric acid, cysteine, or struvite stones
  • * History of bowel surgery
  • * History of colon resection
  • * History of inflammatory bowel disease (Crohn's disease, Ulcerative Colitis)
  • * History of primarily uric acid, cysteine, or struvite stones

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Chicago,

Study Record Dates

2026-08-02