ACTIVE_NOT_RECRUITING

Renal Metabolism in Salt-sensitive Human Blood Pressure

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Salt sensitive hypertension is a significant health problem worldwide and a primary modifiable risk factor for renal, cardiovascular, and cerebrovascular diseases. Yet, the underlying mechanisms remain poorly understood. The proposed study determines how renal oxygenation and substrate metabolism differs between individuals with and without salt sensitivity, with the ultimate goal of identifying mechanisms, diagnostic criteria, and treatment strategies for salt sensitive hypertension.

Official Title

Renal Metabolism in Salt-sensitive Human Blood Pressure

Quick Facts

Study Start:2021-11-01
Study Completion:2030-01-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05369416

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:30 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * English speaking subjects
  2. * With a spectrum of BPs, ranging from those with Elevated BP through Stage 1 HTN, as defined by the 2017 ACC/AHA HTN guidelines
  1. * Non-English speakers
  2. * BP ≤120/80 \& ≥ 140/90 mmHg
  3. * H/o diabetes, congestive heart failure, cirrhosis of the liver, hypokalemia \& other
  4. * electrolyte disturbances
  5. * H/o kidney disease
  6. * Use of glucocorticoids
  7. * Pregnant or nursing mothers
  8. * Presence of bleeding disorders
  9. * Use of anti-platelet and anticoagulant agents such as clopidogrel, aspirin, dabigatran, rivaroxaban etc
  10. * Daily sodium intake ≥ 6000 mg/day
  11. * Presence of pacemaker or other metallic implants
  12. * Allergy to iodinated contrast
  13. * Allergy to shellfish
  14. * Claustrophobia

Contacts and Locations

Principal Investigator

Srividya Kidambi, MD
PRINCIPAL_INVESTIGATOR
Medical College of Wisconsin

Study Locations (Sites)

Medical College of Wisconsin /Froedtert Hospital
Milwaukee, Wisconsin, 53226
United States

Collaborators and Investigators

Sponsor: Medical College of Wisconsin

  • Srividya Kidambi, MD, PRINCIPAL_INVESTIGATOR, Medical College of Wisconsin

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-11-01
Study Completion Date2030-01-30

Study Record Updates

Study Start Date2021-11-01
Study Completion Date2030-01-30

Terms related to this study

Keywords Provided by Researchers

  • hypertension
  • high blood pressure
  • salt

Additional Relevant MeSH Terms

  • Hypertension