Renal Metabolism in Salt-sensitive Human Blood Pressure

Description

Salt sensitive hypertension is a significant health problem worldwide and a primary modifiable risk factor for renal, cardiovascular, and cerebrovascular diseases. Yet, the underlying mechanisms remain poorly understood. The proposed study determines how renal oxygenation and substrate metabolism differs between individuals with and without salt sensitivity, with the ultimate goal of identifying mechanisms, diagnostic criteria, and treatment strategies for salt sensitive hypertension.

Conditions

Hypertension

Study Overview

Study Details

Study overview

Salt sensitive hypertension is a significant health problem worldwide and a primary modifiable risk factor for renal, cardiovascular, and cerebrovascular diseases. Yet, the underlying mechanisms remain poorly understood. The proposed study determines how renal oxygenation and substrate metabolism differs between individuals with and without salt sensitivity, with the ultimate goal of identifying mechanisms, diagnostic criteria, and treatment strategies for salt sensitive hypertension.

Renal Metabolism in Salt-sensitive Human Blood Pressure

Renal Metabolism in Salt-sensitive Human Blood Pressure

Condition
Hypertension
Intervention / Treatment

-

Contacts and Locations

Milwaukee

Medical College of Wisconsin /Froedtert Hospital, Milwaukee, Wisconsin, United States, 53226

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English speaking subjects
  • * With a spectrum of BPs, ranging from those with Elevated BP through Stage 1 HTN, as defined by the 2017 ACC/AHA HTN guidelines
  • * Non-English speakers
  • * BP ≤120/80 \& ≥ 140/90 mmHg
  • * H/o diabetes, congestive heart failure, cirrhosis of the liver, hypokalemia \& other
  • * electrolyte disturbances
  • * H/o kidney disease
  • * Use of glucocorticoids
  • * Pregnant or nursing mothers
  • * Presence of bleeding disorders
  • * Use of anti-platelet and anticoagulant agents such as clopidogrel, aspirin, dabigatran, rivaroxaban etc
  • * Daily sodium intake ≥ 6000 mg/day
  • * Presence of pacemaker or other metallic implants
  • * Allergy to iodinated contrast
  • * Allergy to shellfish
  • * Claustrophobia

Ages Eligible for Study

30 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Medical College of Wisconsin,

Srividya Kidambi, MD, PRINCIPAL_INVESTIGATOR, Medical College of Wisconsin

Study Record Dates

2030-01-30