RECRUITING

Blood Biomarkers in Pediatric Kidney Transplant Recipients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The objective of the proposed study is to assess whether a blood biomarker can be used to monitor the response to rejection treatment in pediatric kidney transplant recipients with biopsy-proven acute cellular or antibody mediated rejection. The study hypothesizes that blood gene expression profile and donor-derived cell-free DNA biomarkers (omnigraf) can be used to predict acute rejection and monitor its response to treatment.

Official Title

Use of Blood Gene Expression Profile and Donor-derived Cell-free DNA to Monitor Response to Treatment After Biopsy-proven Acute Rejection in Pediatric Kidney Transplant Recipients

Quick Facts

Study Start:2023-08-21
Study Completion:2026-08-27
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05477082

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified to 21 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Kidney transplant recipients
  2. * Participants undergoing a for-cause kidney biopsy to rule out graft rejection
  3. * Ages 21 years and less
  1. * Participants who have opted out of research
  2. * Patients, less than 18 years of age, whose parents or legal guardians are illiterate and cannot read.
  3. * Participants, 18 years and older, who are illiterate and cannot read.
  4. * Participants, less than 18 years of age, whose parents or legal guardians do not speak English.
  5. * Participants, 18 years and older, who do not speak English
  6. * Participants who are pregnant as confirmed by medical records

Contacts and Locations

Study Contact

Amy Hanson
CONTACT
612-626-4424
amhanson@umn.edu

Principal Investigator

Sarah Kizilbash, MD
PRINCIPAL_INVESTIGATOR
University of Minnesota

Study Locations (Sites)

University of Minnesota
Minneapolis, Minnesota, 55455
United States

Collaborators and Investigators

Sponsor: University of Minnesota

  • Sarah Kizilbash, MD, PRINCIPAL_INVESTIGATOR, University of Minnesota

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-08-21
Study Completion Date2026-08-27

Study Record Updates

Study Start Date2023-08-21
Study Completion Date2026-08-27

Terms related to this study

Keywords Provided by Researchers

  • acute rejection
  • kidney transplant
  • pediatric
  • biomarker
  • cell free DNA

Additional Relevant MeSH Terms

  • Rejection of Kidney Allograft