Blood Biomarkers in Pediatric Kidney Transplant Recipients

Description

The objective of the proposed study is to assess whether a blood biomarker can be used to monitor the response to rejection treatment in pediatric kidney transplant recipients with biopsy-proven acute cellular or antibody mediated rejection. The study hypothesizes that blood gene expression profile and donor-derived cell-free DNA biomarkers (omnigraf) can be used to predict acute rejection and monitor its response to treatment.

Conditions

Rejection of Kidney Allograft

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Study Overview

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Study Details

Study overview

The objective of the proposed study is to assess whether a blood biomarker can be used to monitor the response to rejection treatment in pediatric kidney transplant recipients with biopsy-proven acute cellular or antibody mediated rejection. The study hypothesizes that blood gene expression profile and donor-derived cell-free DNA biomarkers (omnigraf) can be used to predict acute rejection and monitor its response to treatment.

Use of Blood Gene Expression Profile and Donor-derived Cell-free DNA to Monitor Response to Treatment After Biopsy-proven Acute Rejection in Pediatric Kidney Transplant Recipients

Blood Biomarkers in Pediatric Kidney Transplant Recipients

Condition
Rejection of Kidney Allograft
Intervention / Treatment

-

Contacts and Locations

Minneapolis

University of Minnesota, Minneapolis, Minnesota, United States, 55455

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Kidney transplant recipients
  • * Participants undergoing a for-cause kidney biopsy to rule out graft rejection
  • * Ages 21 years and less
  • * Participants who have opted out of research
  • * Patients, less than 18 years of age, whose parents or legal guardians are illiterate and cannot read.
  • * Participants, 18 years and older, who are illiterate and cannot read.
  • * Participants, less than 18 years of age, whose parents or legal guardians do not speak English.
  • * Participants, 18 years and older, who do not speak English
  • * Participants who are pregnant as confirmed by medical records

Ages Eligible for Study

to 21 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Minnesota,

Sarah Kizilbash, MD, PRINCIPAL_INVESTIGATOR, University of Minnesota

Study Record Dates

2026-08-27