RECRUITING

Reducing Blood Pressure in Mid-life Adult Binge Drinkers

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Conditions

Alcohol DrinkingBinge DrinkingBlood PressureAlcohol AbstinenceAgingLifestyle FactorsVasodilationBehavioral ProblemExercise trainingHigh-intensity interval trainingMidlife adultsMiddle-agedMicrovascular functionSympathetic nerve activity

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers. Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers

Official Title

Reducing Blood Pressure in Mid-life Adult Binge Drinkers: the Role of Microvascular Function and Sympathetic Activity

Quick Facts

Study Start:2022-11-21
Study Completion:2025-04-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05522075

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 64 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Men and women (50-64 years of age) who do not drink alcohol, who drink at moderate levels, or who binge drink
  2. * Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr).
  3. * Subjects who can speak and understand English.
  1. * a history of diabetes, cardiovascular disease, liver, or renal disease
  2. * current or history of smoking and illicit drug use
  3. * blood pressure ≥160/100 mm Hg
  4. * other known traditional cardiovascular disease risks: obesity (BMI≥35 kg/m2), or hyperlipidemia (total cholesterol\>230 mg/dl and/or LDL cholesterol\>160 mg/dl)
  5. * active infection (in the past 2 months)
  6. * a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid)
  7. * unstable body weight (\>5% change during the past 6 months)
  8. * regular aerobic exercise training (i.e., they engage in 30 min of structured aerobic exercise at least 3 times per week)
  9. * current use of hormone replacement therapy (i.e., estrogen, progesterone, and testosterone)

Contacts and Locations

Study Contact

Chueh-Lung Hwang, PhD
CONTACT
8172729722
chuehlung.hwang@uta.edu

Principal Investigator

Chueh-Lung Hwang, PhD
PRINCIPAL_INVESTIGATOR
University of Texas at Arlington

Study Locations (Sites)

University of Texas at Arlington
Arlington, Texas, 76010
United States

Collaborators and Investigators

Sponsor: The University of Texas at Arlington

  • Chueh-Lung Hwang, PhD, PRINCIPAL_INVESTIGATOR, University of Texas at Arlington

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-11-21
Study Completion Date2025-04-30

Study Record Updates

Study Start Date2022-11-21
Study Completion Date2025-04-30

Terms related to this study

Keywords Provided by Researchers

  • Exercise training
  • High-intensity interval training
  • Midlife adults
  • Middle-aged
  • Microvascular function
  • Sympathetic nerve activity

Additional Relevant MeSH Terms

  • Alcohol Drinking
  • Binge Drinking
  • Blood Pressure
  • Alcohol Abstinence
  • Aging
  • Lifestyle Factors
  • Vasodilation
  • Behavioral Problem