Reducing Blood Pressure in Mid-life Adult Binge Drinkers

Description

This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers. Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers

Conditions

Alcohol Drinking, Binge Drinking, Blood Pressure, Alcohol Abstinence, Aging, Lifestyle Factors, Vasodilation, Behavioral Problem

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Study Overview

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Study Details

Study overview

This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers. Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers

Reducing Blood Pressure in Mid-life Adult Binge Drinkers: the Role of Microvascular Function and Sympathetic Activity

Reducing Blood Pressure in Mid-life Adult Binge Drinkers

Condition
Alcohol Drinking
Intervention / Treatment

-

Contacts and Locations

Arlington

University of Texas at Arlington, Arlington, Texas, United States, 76010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Men and women (50-64 years of age) who do not drink alcohol, who drink at moderate levels, or who binge drink
  • * Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr).
  • * Subjects who can speak and understand English.
  • * a history of diabetes, cardiovascular disease, liver, or renal disease
  • * current or history of smoking and illicit drug use
  • * blood pressure ≥160/100 mm Hg
  • * other known traditional cardiovascular disease risks: obesity (BMI≥35 kg/m2), or hyperlipidemia (total cholesterol\>230 mg/dl and/or LDL cholesterol\>160 mg/dl)
  • * active infection (in the past 2 months)
  • * a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid)
  • * unstable body weight (\>5% change during the past 6 months)
  • * regular aerobic exercise training (i.e., they engage in 30 min of structured aerobic exercise at least 3 times per week)
  • * current use of hormone replacement therapy (i.e., estrogen, progesterone, and testosterone)

Ages Eligible for Study

50 Years to 64 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

The University of Texas at Arlington,

Chueh-Lung Hwang, PhD, PRINCIPAL_INVESTIGATOR, University of Texas at Arlington

Study Record Dates

2025-04-30