RECRUITING

Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to gain a better understanding of why some individuals who have suffered a stroke experience post-stroke cognitive decline. Specifically this study is testing whether global disruption of the blood-brain barrier detected at the time of the stroke is informative about the risk of post-stroke cognitive decline over the next 3 years.

Official Title

Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline

Quick Facts

Study Start:2022-04-01
Study Completion:2027-04-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05556395

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Acute ischemic stroke demonstrated on an MRI scan that includes perfusion imaging with an exogenous contrast agent
  1. * Inability to perform telephone-based cognitive assessments

Contacts and Locations

Study Contact

Pooja Patel
CONTACT
410 502 5355
ppate120@jhmi.edu

Principal Investigator

Richard Leigh, MD
PRINCIPAL_INVESTIGATOR
Johns Hopkins University

Study Locations (Sites)

Johns Hopkins Hospital
Baltimore, Maryland, 21287
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Richard Leigh, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-04-01
Study Completion Date2027-04-01

Study Record Updates

Study Start Date2022-04-01
Study Completion Date2027-04-01

Terms related to this study

Keywords Provided by Researchers

  • blood-brain barrier
  • post-stroke cognitive impairment and dementia
  • vascular cognitive impairment and dementia
  • Alzheimer's disease and related dementias
  • stroke

Additional Relevant MeSH Terms

  • Ischemic Stroke