RECRUITING

Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

Description

The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).

Study Overview

Study Details

Study overview

The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).

Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

Condition
Blood Pressure
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35233

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Male or Female, age 18-89
  • 2. Chronic pain for more than 3 months
  • 3. Willing to visit a research lab
  • 4. Willing to undergo a blood draw
  • 5. Able to provide written informed consent
  • 1. History of neurological disease (e.g., dementias, Parkinson's)
  • 2. History of stroke
  • 3. Current diagnosis of cancer
  • 4. Subject is unwilling or unable to comply with the protocol

Ages Eligible for Study

18 Years to 89 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Alabama at Birmingham,

Marshall Holland, MD, PRINCIPAL_INVESTIGATOR, The University of Alabama at Birmingham

Study Record Dates

2030-05-01