RECRUITING

Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).

Official Title

Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

Quick Facts

Study Start:2022-08-02
Study Completion:2030-05-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05556902

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 89 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Male or Female, age 18-89
  2. 2. Chronic pain for more than 3 months
  3. 3. Willing to visit a research lab
  4. 4. Willing to undergo a blood draw
  5. 5. Able to provide written informed consent
  6. 1. History of neurological disease (e.g., dementias, Parkinson's)
  7. 2. History of stroke
  8. 3. Current diagnosis of cancer
  9. 4. Subject is unwilling or unable to comply with the protocol
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Chris Gonzalez, MS
CONTACT
(205) 975-3732
clgonzalez@uabmc.edu

Principal Investigator

Marshall Holland, MD
PRINCIPAL_INVESTIGATOR
The University of Alabama at Birmingham

Study Locations (Sites)

University of Alabama at Birmingham
Birmingham, Alabama, 35233
United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

  • Marshall Holland, MD, PRINCIPAL_INVESTIGATOR, The University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-08-02
Study Completion Date2030-05-01

Study Record Updates

Study Start Date2022-08-02
Study Completion Date2030-05-01

Terms related to this study

Keywords Provided by Researchers

  • Spinal Cord Stimulation
  • Epidural Spinal Cord Stimulation
  • SCS
  • Arterial Blood Pressure

Additional Relevant MeSH Terms

  • Blood Pressure
  • Low Back Pain
  • Hypertension