RECRUITING

Efficacy of Reading Intervention on the Brain Connectivity in Autism

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overarching goal of this proposal is to test the impact of a comprehensive reading intervention program (Visualizing and Verbalizing) on changing the neurobiological mechanisms underlying reading comprehension deficits in children with autism spectrum disorders (ASD). To this end, the investigators will test a group of children with ASD and NT control participants who share common characteristic of average level decoding along with below average reading comprehension. Inclusion of an additional NT group that does not have any reading comprehension deficit will provide another control for additional comparisons.

Official Title

The Efficacy of a Visualizing Reading Intervention on Improving the Brain's Reading Network in Children With Autism

Quick Facts

Study Start:2019-01-10
Study Completion:2024-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05568056

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:7 Years to 13 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. 1. Full Scale and Verbal IQs \> 70
  2. 2. be 7-13 years of age;
  3. 3. no antipsychotics for at least one month
  4. 4. no anti-epileptics/convulsants for at least one week
  5. 5. no stimulants for 24 hours prior to testing; and
  6. 6. subjects with ASD meet DSM-V criteria (American Psychiatric Association, 2013)
  7. 7. Neurotypical participants will be medically healthy (below ASD symptom cutoff score on the SCQ (Rutter, Bailey, \& Lord, 2003); without a self-reported and parent- reported history of neurologic or psychiatric disorders; and without a family history of ASD)
  8. 8. The NT-EXP participants need to have similar profile of reading comprehension difficulties as the ASD participants with average decoding accompanied by below average reading comprehension.
  1. 1. contraindication for MRI (cardiac pacemaker, aneurysm clip, cochlear implants, Intra Uterine Device, shrapnel, neurostimulators, defibrillator, artificial heart valve, or history of metal fragments in eyes, pregnancy, a body weight of more than 250 lbs. and claustrophobia)
  2. 2. seizure disorder or history of head injury

Contacts and Locations

Study Contact

Rajesh Kana, PhD
CONTACT
2053481391
rkkana@ua.edu
Jennifer Camp
CONTACT
jrcamp@ua.edu

Study Locations (Sites)

University of Alabama
Tuscaloosa, Alabama, 35487
United States

Collaborators and Investigators

Sponsor: University of Alabama, Tuscaloosa

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-01-10
Study Completion Date2024-08-31

Study Record Updates

Study Start Date2019-01-10
Study Completion Date2024-08-31

Terms related to this study

Additional Relevant MeSH Terms

  • Autism Spectrum Disorder
  • Autism
  • Reading Problem