Efficacy of Reading Intervention on the Brain Connectivity in Autism

Description

The overarching goal of this proposal is to test the impact of a comprehensive reading intervention program (Visualizing and Verbalizing) on changing the neurobiological mechanisms underlying reading comprehension deficits in children with autism spectrum disorders (ASD). To this end, the investigators will test a group of children with ASD and NT control participants who share common characteristic of average level decoding along with below average reading comprehension. Inclusion of an additional NT group that does not have any reading comprehension deficit will provide another control for additional comparisons.

Conditions

Autism Spectrum Disorder, Autism, Reading Problem

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Study Overview

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Study Details

Study overview

The overarching goal of this proposal is to test the impact of a comprehensive reading intervention program (Visualizing and Verbalizing) on changing the neurobiological mechanisms underlying reading comprehension deficits in children with autism spectrum disorders (ASD). To this end, the investigators will test a group of children with ASD and NT control participants who share common characteristic of average level decoding along with below average reading comprehension. Inclusion of an additional NT group that does not have any reading comprehension deficit will provide another control for additional comparisons.

The Efficacy of a Visualizing Reading Intervention on Improving the Brain's Reading Network in Children With Autism

Efficacy of Reading Intervention on the Brain Connectivity in Autism

Condition
Autism Spectrum Disorder
Intervention / Treatment

-

Contacts and Locations

Tuscaloosa

University of Alabama, Tuscaloosa, Alabama, United States, 35487

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Full Scale and Verbal IQs \> 70
  • 2. be 7-13 years of age;
  • 3. no antipsychotics for at least one month
  • 4. no anti-epileptics/convulsants for at least one week
  • 5. no stimulants for 24 hours prior to testing; and
  • 6. subjects with ASD meet DSM-V criteria (American Psychiatric Association, 2013)
  • 7. Neurotypical participants will be medically healthy (below ASD symptom cutoff score on the SCQ (Rutter, Bailey, \& Lord, 2003); without a self-reported and parent- reported history of neurologic or psychiatric disorders; and without a family history of ASD)
  • 8. The NT-EXP participants need to have similar profile of reading comprehension difficulties as the ASD participants with average decoding accompanied by below average reading comprehension.
  • 1. contraindication for MRI (cardiac pacemaker, aneurysm clip, cochlear implants, Intra Uterine Device, shrapnel, neurostimulators, defibrillator, artificial heart valve, or history of metal fragments in eyes, pregnancy, a body weight of more than 250 lbs. and claustrophobia)
  • 2. seizure disorder or history of head injury

Ages Eligible for Study

7 Years to 13 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Alabama, Tuscaloosa,

Study Record Dates

2024-08-31