RECRUITING

Allergy and Immunology Natural History Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic inflammation or Immune Dysregulation. Patients determined by clinical history and outside evaluations to be of interest will be consented and enrolled into this study. Blood specimens, stored blood products and derivatives, saliva, hair, fingernail clippings, cord blood, umbilical cord, bone marrow, tissue biopsies and/or buccal swabs from such patients and/or their family members will be obtained for research studies related to understanding genetic and immunopathogenic bases of these diseases. Outside medical records may be obtained, and patient evaluations may be performed to correlate to research laboratory testing results.

Official Title

Natural History Study for Genetic Diseases of Allergic Inflammation and Immune Dysregulation

Quick Facts

Study Start:2010-07-16
Study Completion:2025-01-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05584488

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified to 99 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Subjects, ages birth to 99 years old, known to have or suspected of having an inherited disorder of allergic inflammation, or mast cell homeostasis, or activation or immune dysregulation.
  2. * Blood relatives of enrolled subjects will be eligible for enrollment.
  3. * There will be no discrimination as to age, gender, race, or disability.
  4. * Subjects/guardians must be willing and able to give informed consent.
  5. * Subjects must agree to have their blood stored for future studies of the immune system and/or other medical conditions.
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Joshua D. Milner, MD
CONTACT
212-305-2100
jdm2249@cumc.columbia
Yannett Franklin
CONTACT
212-305-0473
ym206@cumc.columbia.edu

Principal Investigator

Joshua D. Milner, MD
PRINCIPAL_INVESTIGATOR
Columbia University

Study Locations (Sites)

Columbia University Irving Medical Center / NewYork-Presbyterian Hospital
New York, New York, 10032
United States

Collaborators and Investigators

Sponsor: Columbia University

  • Joshua D. Milner, MD, PRINCIPAL_INVESTIGATOR, Columbia University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2010-07-16
Study Completion Date2025-01-01

Study Record Updates

Study Start Date2010-07-16
Study Completion Date2025-01-01

Terms related to this study

Keywords Provided by Researchers

  • Eosinophilic Disease
  • Anaphylaxis
  • Elevated IgE levels
  • Autoimmune diseases
  • Allergy
  • Asthma
  • Atopic Dermatitis
  • Allergic Fhinitis
  • Food Allergy
  • Immunodeficiency Diseases
  • Immunodysregulatory Diseases
  • Piebaldism
  • Urticaria
  • Angioedema

Additional Relevant MeSH Terms

  • Immune Deficiency
  • Immune Dysregulation Disorder
  • Allergic Inflammation