Allergy and Immunology Natural History Study

Description

This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic inflammation or Immune Dysregulation. Patients determined by clinical history and outside evaluations to be of interest will be consented and enrolled into this study. Blood specimens, stored blood products and derivatives, saliva, hair, fingernail clippings, cord blood, umbilical cord, bone marrow, tissue biopsies and/or buccal swabs from such patients and/or their family members will be obtained for research studies related to understanding genetic and immunopathogenic bases of these diseases. Outside medical records may be obtained, and patient evaluations may be performed to correlate to research laboratory testing results.

Conditions

Immune Deficiency, Immune Dysregulation Disorder, Allergic Inflammation

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Study Overview

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Study Details

Study overview

This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic inflammation or Immune Dysregulation. Patients determined by clinical history and outside evaluations to be of interest will be consented and enrolled into this study. Blood specimens, stored blood products and derivatives, saliva, hair, fingernail clippings, cord blood, umbilical cord, bone marrow, tissue biopsies and/or buccal swabs from such patients and/or their family members will be obtained for research studies related to understanding genetic and immunopathogenic bases of these diseases. Outside medical records may be obtained, and patient evaluations may be performed to correlate to research laboratory testing results.

Natural History Study for Genetic Diseases of Allergic Inflammation and Immune Dysregulation

Allergy and Immunology Natural History Study

Condition
Immune Deficiency
Intervention / Treatment

-

Contacts and Locations

New York

Columbia University Irving Medical Center / NewYork-Presbyterian Hospital, New York, New York, United States, 10032

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects, ages birth to 99 years old, known to have or suspected of having an inherited disorder of allergic inflammation, or mast cell homeostasis, or activation or immune dysregulation.
  • * Blood relatives of enrolled subjects will be eligible for enrollment.
  • * There will be no discrimination as to age, gender, race, or disability.
  • * Subjects/guardians must be willing and able to give informed consent.
  • * Subjects must agree to have their blood stored for future studies of the immune system and/or other medical conditions.

Ages Eligible for Study

to 99 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Columbia University,

Joshua D. Milner, MD, PRINCIPAL_INVESTIGATOR, Columbia University

Study Record Dates

2025-01-01