RECRUITING

Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers

Description

Spousal caregivers of Alzheimer's Dementia (AD) patients have an elevated risk of developing AD in the future. Past studies have shown the presence of serum indicators correlated with gut biome dysfunction in AD patients. We hypothesize that the same gut biome dysfunction may be present in spousal caregivers of AD patients.

Conditions

Alzheimer DiseaseGut Biome
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Related Conditions:

Alzheimer DiseaseGut Biome

Study Overview

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Study Details

Study overview

Spousal caregivers of Alzheimer's Dementia (AD) patients have an elevated risk of developing AD in the future. Past studies have shown the presence of serum indicators correlated with gut biome dysfunction in AD patients. We hypothesize that the same gut biome dysfunction may be present in spousal caregivers of AD patients.

Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers

Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers

Condition
Alzheimer Disease
Intervention / Treatment

-

Contacts and Locations

Charlottesville

University of Virginia, Charlottesville, Virginia, United States, 22908-0710

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. patients with AD whose clinical dementia rating (CDR) is \> 1
  • 2. Spouses of Patients in the above group Or
  • 3. Healthy adult unrelated to groups 1 and 2, with no history of dementia And
  • 4. Regardless of the grouping, the prospective subject must be between 65 and 90 years old
  • 1. Familial Alzheimer's Disease (AD)
  • 2. Severe cardiovascular disease
  • 3. Severe respiratory system disease
  • 4. Severe liver disease
  • 5. Severe kidney disease
  • 6. Severe central nervous system diseases
  • 7. Having a lifespan of fewer than 3 months
  • 8. History of psychiatric illness
  • 9. Major neurological diseases other than AD
  • 10. Current use of corticosteroids, antibiotics, or bowel motility modification agents
  • 11. Any history of Alcoholism or illicit drug dependence
  • 12. Previous inclusion in this study
  • 13. Difficulty with follow-up or poor compliance
  • 14. Severe hearing impairment
  • 15. Severe vision impairment

Ages Eligible for Study

65 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Virginia,

Study Record Dates

2024-11-30