RECRUITING

Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers

Conditions

Alzheimer Disease Gut Biome Alzheimers biome

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Spousal caregivers of Alzheimer's Dementia (AD) patients have an elevated risk of developing AD in the future. Past studies have shown the presence of serum indicators correlated with gut biome dysfunction in AD patients. We hypothesize that the same gut biome dysfunction may be present in spousal caregivers of AD patients.

Official Title

Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers

Quick Facts

Study Start:2022-12-15

Study Completion:2024-11-30

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05601856

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years to 90 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. patients with AD whose clinical dementia rating (CDR) is \> 1 2. Spouses of Patients in the above group Or 3. Healthy adult unrelated to groups 1 and 2, with no history of dementia And 4. Regardless of the grouping, the prospective subject must be between 65 and 90 years old	1. Familial Alzheimer's Disease (AD) 2. Severe cardiovascular disease 3. Severe respiratory system disease 4. Severe liver disease 5. Severe kidney disease 6. Severe central nervous system diseases 7. Having a lifespan of fewer than 3 months 8. History of psychiatric illness 9. Major neurological diseases other than AD 10. Current use of corticosteroids, antibiotics, or bowel motility modification agents 11. Any history of Alcoholism or illicit drug dependence 12. Previous inclusion in this study 13. Difficulty with follow-up or poor compliance 14. Severe hearing impairment 15. Severe vision impairment

Inclusion Criteria

Exclusion Criteria

1. patients with AD whose clinical dementia rating (CDR) is \> 1
2. Spouses of Patients in the above group Or
3. Healthy adult unrelated to groups 1 and 2, with no history of dementia And
4. Regardless of the grouping, the prospective subject must be between 65 and 90 years old

1. Familial Alzheimer's Disease (AD)
2. Severe cardiovascular disease
3. Severe respiratory system disease
4. Severe liver disease
5. Severe kidney disease
6. Severe central nervous system diseases
7. Having a lifespan of fewer than 3 months
8. History of psychiatric illness
9. Major neurological diseases other than AD
10. Current use of corticosteroids, antibiotics, or bowel motility modification agents
11. Any history of Alcoholism or illicit drug dependence
12. Previous inclusion in this study
13. Difficulty with follow-up or poor compliance
14. Severe hearing impairment
15. Severe vision impairment

Contacts and Locations

Study Contact

Keita Ikeda, PHD

CONTACT

9195931174

keita.ikeda@virginia.edu

ZHIYI ZUO, MD PHD

CONTACT

4349824481

zz3c@uvahealth.org

Study Locations (Sites)

University of Virginia

Charlottesville, Virginia, 22908-0710

United States

Collaborators and Investigators

Sponsor: University of Virginia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-12-15

Study Completion Date2024-11-30

Study Record Updates

Study Start Date2022-12-15

Study Completion Date2024-11-30

Terms related to this study

Keywords Provided by Researchers

Alzheimers
biome

Additional Relevant MeSH Terms

Alzheimer Disease
Gut Biome