ACTIVE_NOT_RECRUITING

A Study of YL202 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer and Breast Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a phase 1, multicenter, open-label, first-in-human study of YL202 conducted in the United States and China. The study will evaluate the safety and tolerability of YL202 in patients with locally advanced or metastatic epidermal growth factor receptor (EGFR)-mutated NSCLC or hormone receptor (HR)-positive and HER2-negative BC, which have been heavily treated by standard treatment.

Official Title

A Phase 1, Multicenter, Open-label, First-in-human Study of YL202 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer and Breast Cancer

Quick Facts

Study Start:2022-12-20
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05653752

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Locations (Sites)

BRCR Global
Plantation, Florida, 33322
United States
Karmanos Cancer Institute
Detroit, Michigan, 48201
United States
The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030
United States
Next Oncology-Dallas
Irving, Texas, 75039
United States
UT health east Texas HOPE Cancer Center
Tyler, Texas, 75701
United States
Next Oncology-Virginia
Fairfax, Virginia, 22031
United States
Summit Cancer Center
Spokane Valley, Washington, 99216
United States

Collaborators and Investigators

Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-12-20
Study Completion Date2026-12

Study Record Updates

Study Start Date2022-12-20
Study Completion Date2026-12

Terms related to this study

Additional Relevant MeSH Terms

  • Non Small Cell Lung Cancer
  • Breast Cancer