COMPLETED

NIRST and ICG-based Perfusion Imaging in Acute Compartment Syndrome

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a prospective observational study of patients with suspected Acute Compartment Syndrome. The primary objective of this work is to determine whether intensity changes associated with the NIRST signal, reflecting oxy- and deoxy-hemaglobin and water concentrations or ICG fluorescence signal, reflecting tissue perfusion, can be associated with development of Acute Compartment Syndrome and identification of at-risk soft tissue and muscle.

Official Title

Near-infrared Spectroscopic Tomography (NIRST) and ICG-based Perfusion Imaging to Diagnose and Assess Muscle Viability in High Energy Trauma at Risk for Acute Compartment Syndrome: A Pilot Study

Quick Facts

Study Start:2023-05-12
Study Completion:2025-09-16
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05672381

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Not specified
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18 years or older
  2. * Clinical suspicion of acute compartment syndrome based on orthopaedic provider assessment. Clinical suspicion would be based upon the presence of one or more of these findings:
  3. * Pain out of proportion to visible findings
  4. * Escalating doses of pain medication
  5. * Pain with passive stretch of toes and/or fingers
  6. * Pallor, paresthesias, pulselessness
  7. * Tense soft tissues
  8. * High energy tibia or forearm fracture
  9. * Provision of informed consent
  1. * History of allergy to ICG and/or iodine
  2. * Pregnant women or nursing mothers
  3. * Any patient with an open wound for whom NIRST device cannot be applied \>4cm from the open wound will be excluded from NIRST imaging.

Contacts and Locations

Principal Investigator

Ida L Gitajn, MD, MS
PRINCIPAL_INVESTIGATOR
Dartmouth-Hitchcock Medical Center

Study Locations (Sites)

Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03766
United States

Collaborators and Investigators

Sponsor: Dartmouth-Hitchcock Medical Center

  • Ida L Gitajn, MD, MS, PRINCIPAL_INVESTIGATOR, Dartmouth-Hitchcock Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-05-12
Study Completion Date2025-09-16

Study Record Updates

Study Start Date2023-05-12
Study Completion Date2025-09-16

Terms related to this study

Additional Relevant MeSH Terms

  • Compartment Syndromes
  • Compartment Syndrome of Lower Leg
  • Compartment Syndrome of Forearm