NIRST and ICG-based Perfusion Imaging in Acute Compartment Syndrome

Description

This is a prospective observational study of patients with suspected Acute Compartment Syndrome. The primary objective of this work is to determine whether intensity changes associated with the NIRST signal, reflecting oxy- and deoxy-hemaglobin and water concentrations or ICG fluorescence signal, reflecting tissue perfusion, can be associated with development of Acute Compartment Syndrome and identification of at-risk soft tissue and muscle.

Conditions

Compartment Syndromes, Compartment Syndrome of Lower Leg, Compartment Syndrome of Forearm

Study Overview

Study Details

Study overview

This is a prospective observational study of patients with suspected Acute Compartment Syndrome. The primary objective of this work is to determine whether intensity changes associated with the NIRST signal, reflecting oxy- and deoxy-hemaglobin and water concentrations or ICG fluorescence signal, reflecting tissue perfusion, can be associated with development of Acute Compartment Syndrome and identification of at-risk soft tissue and muscle.

Near-infrared Spectroscopic Tomography (NIRST) and ICG-based Perfusion Imaging to Diagnose and Assess Muscle Viability in High Energy Trauma At Risk for Acute Compartment Syndrome: a Pilot Study

NIRST and ICG-based Perfusion Imaging in Acute Compartment Syndrome

Condition
Compartment Syndromes
Intervention / Treatment

-

Contacts and Locations

Lebanon

Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States, 03766

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18 years or older
  • * Clinical suspicion of acute compartment syndrome based on orthopaedic provider assessment. Clinical suspicion would be based upon the presence of one or more of these findings:
  • * Pain out of proportion to visible findings
  • * Escalating doses of pain medication
  • * Pain with passive stretch of toes and/or fingers
  • * Pallor, paresthesias, pulselessness
  • * Tense soft tissues
  • * High energy tibia or forearm fracture
  • * Provision of informed consent
  • * History of allergy to ICG and/or iodine
  • * Pregnant women or nursing mothers
  • * Any patient with an open wound for whom NIRST device cannot be applied \>4cm from the open wound will be excluded from NIRST imaging.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Dartmouth-Hitchcock Medical Center,

Ida L Gitajn, MD, MS, PRINCIPAL_INVESTIGATOR, Dartmouth-Hitchcock Medical Center

Study Record Dates

2027-01