COMPLETED

Novel Treatment for Dental Ankylosis

Conditions

Dental Ankylosis Vibration Electric toothbrush Mini-implant Heavy force

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The study is to determine whether one (or two) new method(s) will help treat dental ankylosis. This study tackles the challenging tooth-bone fusion disorder of ankylosis. In growing patients, ankylosis causes significant developmental bone defects due to its inhibition of the vertical growth of the affected alveolar bone area.

Official Title

Novel Treatment for Dental Ankylosis

Quick Facts

Study Start:2023-07-10

Study Completion:2025-12-16

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT05695105

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:6 Years to 30 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:CHILD, ADULT

Inclusion Criteria	Exclusion Criteria
* Full informed consent and/or informed assent (minors) * Be willing and able to comply with all study requirements * Male or female * Aged 6-30 * Clinically diagnosed to have either an ankylosed deciduous tooth or a non-third molar mildly- to moderately- ankylosed permanent tooth, and with crown partially visible in the oral cavity. Clinical diagnosis of ankylosis includes the following factors: dental trauma history, infra-eruption with no apparent mechanical obstruction or other cause, contralateral tooth in occlusal contact for over one year, decreased alveolar bone height, no or reduced tooth mobility, and x-ray or cone-beam computer tomography (CBCT) imaging indications of an obliterated PDL space. Ultimately, the diagnosis will be confirmed by lack of tooth movement discovered during orthodontic treatment or when subjected to a heavy force through our study (Phelan M K, et al. 1990). * English speaking (primary language or fluent)	* Severe and extensive ankylosis of permanent teeth as diagnosed through CBCT * Primary failure of eruption with previous orthodontic treatment * Any systemic disorders particularly those affecting bleeding or skeletal health * Any systemic medications * Any mental or developmental disorders that affect patient understanding or compliance * Allergic to our local anesthetic drug * Can pass an infectious disease to someone else right now (e.g., having a flu) * Is pregnant * Has a history of smoking * Have not reached the age of 6 or older than age of 30 * Not cooperative enough during dental examinations * The dentist finds out that he/she is not able to keep the mini-implant, the brackets and the wires in place around the tooth that is being treated * Not fluent in English

Inclusion Criteria

Exclusion Criteria

* Full informed consent and/or informed assent (minors)
* Be willing and able to comply with all study requirements
* Male or female
* Aged 6-30
* Clinically diagnosed to have either an ankylosed deciduous tooth or a non-third molar mildly- to moderately- ankylosed permanent tooth, and with crown partially visible in the oral cavity. Clinical diagnosis of ankylosis includes the following factors: dental trauma history, infra-eruption with no apparent mechanical obstruction or other cause, contralateral tooth in occlusal contact for over one year, decreased alveolar bone height, no or reduced tooth mobility, and x-ray or cone-beam computer tomography (CBCT) imaging indications of an obliterated PDL space. Ultimately, the diagnosis will be confirmed by lack of tooth movement discovered during orthodontic treatment or when subjected to a heavy force through our study (Phelan M K, et al. 1990).
* English speaking (primary language or fluent)

* Severe and extensive ankylosis of permanent teeth as diagnosed through CBCT
* Primary failure of eruption with previous orthodontic treatment
* Any systemic disorders particularly those affecting bleeding or skeletal health
* Any systemic medications
* Any mental or developmental disorders that affect patient understanding or compliance
* Allergic to our local anesthetic drug
* Can pass an infectious disease to someone else right now (e.g., having a flu)
* Is pregnant
* Has a history of smoking
* Have not reached the age of 6 or older than age of 30
* Not cooperative enough during dental examinations
* The dentist finds out that he/she is not able to keep the mini-implant, the brackets and the wires in place around the tooth that is being treated
* Not fluent in English

Contacts and Locations

Principal Investigator

Wei Huang, DDS, PhD

PRINCIPAL_INVESTIGATOR

Rutgers School of Dental Medicine

Study Locations (Sites)

Rutgers School of Dental Medicine

Newark, New Jersey, 07103

United States

Collaborators and Investigators

Sponsor: Rutgers, The State University of New Jersey

Wei Huang, DDS, PhD, PRINCIPAL_INVESTIGATOR, Rutgers School of Dental Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-10

Study Completion Date2025-12-16

Study Record Updates

Study Start Date2023-07-10

Study Completion Date2025-12-16

Terms related to this study

Keywords Provided by Researchers

Dental ankylosis
Vibration
Electric toothbrush
Mini-implant
Heavy force

Additional Relevant MeSH Terms

Dental Ankylosis