Novel Treatment for Dental Ankylosis

Description

The study is to determine whether one (or two) new method(s) will help treat dental ankylosis. This study tackles the challenging tooth-bone fusion disorder of ankylosis. In growing patients, ankylosis causes significant developmental bone defects due to its inhibition of the vertical growth of the affected alveolar bone area.

Conditions

Dental Ankylosis

Study Overview

Study Details

Study overview

The study is to determine whether one (or two) new method(s) will help treat dental ankylosis. This study tackles the challenging tooth-bone fusion disorder of ankylosis. In growing patients, ankylosis causes significant developmental bone defects due to its inhibition of the vertical growth of the affected alveolar bone area.

Novel Treatment for Dental Ankylosis

Novel Treatment for Dental Ankylosis

Condition
Dental Ankylosis
Intervention / Treatment

-

Contacts and Locations

Newark

Rutgers School of Dental Medicine, Newark, New Jersey, United States, 07103

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Full informed consent and/or informed assent (minors)
  • * Be willing and able to comply with all study requirements
  • * Male or female
  • * Aged 6-30
  • * Clinically diagnosed to have either an ankylosed deciduous tooth or a non-third molar mildly- to moderately- ankylosed permanent tooth, and with crown partially visible in the oral cavity. Clinical diagnosis of ankylosis includes the following factors: dental trauma history, infra-eruption with no apparent mechanical obstruction or other cause, contralateral tooth in occlusal contact for over one year, decreased alveolar bone height, no or reduced tooth mobility, and x-ray or cone-beam computer tomography (CBCT) imaging indications of an obliterated PDL space. Ultimately, the diagnosis will be confirmed by lack of tooth movement discovered during orthodontic treatment or when subjected to a heavy force through our study (Phelan M K, et al. 1990).
  • * English speaking (primary language or fluent)
  • * Severe and extensive ankylosis of permanent teeth as diagnosed through CBCT
  • * Primary failure of eruption with previous orthodontic treatment
  • * Any systemic disorders particularly those affecting bleeding or skeletal health
  • * Any systemic medications
  • * Any mental or developmental disorders that affect patient understanding or compliance
  • * Allergic to our local anesthetic drug
  • * Can pass an infectious disease to someone else right now (e.g., having a flu)
  • * Is pregnant
  • * Has a history of smoking
  • * Have not reached the age of 6 or older than age of 30
  • * Not cooperative enough during dental examinations
  • * The dentist finds out that he/she is not able to keep the mini-implant, the brackets and the wires in place around the tooth that is being treated
  • * Not fluent in English

Ages Eligible for Study

6 Years to 30 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Rutgers, The State University of New Jersey,

Wei Huang, DDS, PhD, PRINCIPAL_INVESTIGATOR, Rutgers School of Dental Medicine

Study Record Dates

2025-12