ACTIVE_NOT_RECRUITING

Fatigability in Long COVID-19

Talk to us

Conditions

Long COVIDresistance exercisefatigueCOVID-19near infrared spectroscopystrength

Quick Navigation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overall goal of this project is to advance the understanding of underlying mechanisms impacting performance fatigability and perceived fatigability in Veterans with post-COVID-19 fatigue and explore the safety and feasibility of a home-based "minimal-dose" resistance exercise program in this population. The central hypothesis is that declines in force capacity, skeletal muscle oxygen extraction, and affective responses to physical activity offer potential mechanisms through which fatigability is increased in Veterans with post-COVID-19 fatigue. Moreover, home-based resistance exercise delivered remotely may provide a safe and feasibility treatment option for targeting neuromuscular and neurobehavioral factors influencing fatigability severity in this population.

Official Title

Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection

Quick Facts

Study Start:2023-07-31
Study Completion:2026-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05699538

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * ambulatory patients (with or without a gait aid)
  2. * 50 years of age or older
  3. * with a confirmed diagnosis of COVID-19 by polymerase chain reaction (PCR) test, antibody test or clinical diagnosis
  4. * the symptom of fatigue reported greater than 12-weeks post-infection (reporting fatigue: yes/no)
  5. * receiving care at the DC VAMC
  6. * the ability to speak and read English, and orientation to person, place, and time
  7. * the comparison group will include ambulatory patients (with or without a gait aid)
  8. * 50 years of age or older
  9. * with a confirmed diagnosis of COVID-19 by PCR test, antibody test or clinical diagnosis
  10. * without the symptom of fatigue reported greater than 12-weeks post-infection
  11. * receiving care at the DC VAMC
  12. * the ability to speak and read English, and orientation to person, place, and time
  1. * \<50 years of age without a confirmed diagnosis of COVID-19 by PCR test
  2. * antibody test or clinical diagnosis or with a confirmed diagnosis of COVID-19 of \<12-weeks
  3. * non-ambulatory individuals
  4. * Veterans who do not use the DC VAMC as their main site for care
  5. * body mass index 40 kg/m2
  6. * diagnosis of psychiatric disorder(s)
  7. * any medically uncontrolled cardiovascular
  8. * musculoskeletal disease, or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe
  9. * any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol
  10. * additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study

Contacts and Locations

Principal Investigator

Jared M. Gollie, PhD
PRINCIPAL_INVESTIGATOR
Washington DC VA Medical Center, Washington, DC

Study Locations (Sites)

Washington DC VA Medical Center, Washington, DC
Washington, District of Columbia, 20422-0001
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Jared M. Gollie, PhD, PRINCIPAL_INVESTIGATOR, Washington DC VA Medical Center, Washington, DC

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-31
Study Completion Date2026-03-31

Study Record Updates

Study Start Date2023-07-31
Study Completion Date2026-03-31

Terms related to this study

Keywords Provided by Researchers

  • resistance exercise
  • fatigue
  • COVID-19
  • near infrared spectroscopy
  • strength

Additional Relevant MeSH Terms

  • Long COVID