Fatigability in Long COVID-19

Description

The overall goal of this project is to advance the understanding of underlying mechanisms impacting performance fatigability and perceived fatigability in Veterans with post-COVID-19 fatigue and explore the safety and feasibility of a home-based "minimal-dose" resistance exercise program in this population. The central hypothesis is that declines in force capacity, skeletal muscle oxygen extraction, and affective responses to physical activity offer potential mechanisms through which fatigability is increased in Veterans with post-COVID-19 fatigue. Moreover, home-based resistance exercise delivered remotely may provide a safe and feasibility treatment option for targeting neuromuscular and neurobehavioral factors influencing fatigability severity in this population.

Conditions

Long COVID

Talk to us

Study Overview

On this page

Study Details

Study overview

The overall goal of this project is to advance the understanding of underlying mechanisms impacting performance fatigability and perceived fatigability in Veterans with post-COVID-19 fatigue and explore the safety and feasibility of a home-based "minimal-dose" resistance exercise program in this population. The central hypothesis is that declines in force capacity, skeletal muscle oxygen extraction, and affective responses to physical activity offer potential mechanisms through which fatigability is increased in Veterans with post-COVID-19 fatigue. Moreover, home-based resistance exercise delivered remotely may provide a safe and feasibility treatment option for targeting neuromuscular and neurobehavioral factors influencing fatigability severity in this population.

Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection

Fatigability in Long COVID-19

Condition
Long COVID
Intervention / Treatment

-

Contacts and Locations

Washington

Washington DC VA Medical Center, Washington, DC, Washington, District of Columbia, United States, 20422-0001

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * ambulatory patients (with or without a gait aid)
  • * 50 years of age or older
  • * with a confirmed diagnosis of COVID-19 by polymerase chain reaction (PCR) test, antibody test or clinical diagnosis
  • * the symptom of fatigue reported greater than 12-weeks post-infection (reporting fatigue: yes/no)
  • * receiving care at the DC VAMC
  • * the ability to speak and read English, and orientation to person, place, and time
  • * the comparison group will include ambulatory patients (with or without a gait aid)
  • * 50 years of age or older
  • * with a confirmed diagnosis of COVID-19 by PCR test, antibody test or clinical diagnosis
  • * without the symptom of fatigue reported greater than 12-weeks post-infection
  • * receiving care at the DC VAMC
  • * the ability to speak and read English, and orientation to person, place, and time
  • * \<50 years of age without a confirmed diagnosis of COVID-19 by PCR test
  • * antibody test or clinical diagnosis or with a confirmed diagnosis of COVID-19 of \<12-weeks
  • * non-ambulatory individuals
  • * Veterans who do not use the DC VAMC as their main site for care
  • * body mass index 40 kg/m2
  • * diagnosis of psychiatric disorder(s)
  • * any medically uncontrolled cardiovascular
  • * musculoskeletal disease, or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe
  • * any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol
  • * additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Jared M. Gollie, PhD, PRINCIPAL_INVESTIGATOR, Washington DC VA Medical Center, Washington, DC

Study Record Dates

2025-06-05