RECRUITING

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.

Official Title

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Quick Facts

Study Start:2022-11-08
Study Completion:2027-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05703386

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Not specified
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Clinical or radiographic evidence of ischemic stroke
  2. * One vascular risk factor (hypertension, hyperlipidemia, or diabetes)
  3. * Evidence of cerebral small vessel disease on MRI
  1. * Inability to complete 3 research MRI scans over 1.25 years

Contacts and Locations

Study Contact

Pooja Patel
CONTACT
410-502-5355
ppate120@jhmi.edu

Principal Investigator

Richard Leigh, MD
PRINCIPAL_INVESTIGATOR
Johns Hopkins University

Study Locations (Sites)

Kennedy Krieger Institute
Baltimore, Maryland, 21205
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Richard Leigh, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-11-08
Study Completion Date2027-03-31

Study Record Updates

Study Start Date2022-11-08
Study Completion Date2027-03-31

Terms related to this study

Keywords Provided by Researchers

  • Cerebral small vessel disease
  • Vascular cognitive impairment and dementia
  • White matter hyperintensities
  • Blood-brain barrier
  • Vascular risk factors
  • Ischemic stroke

Additional Relevant MeSH Terms

  • Ischemic Stroke
  • Hypertension
  • Hyperlipidemias
  • Diabetes