Imaging the Pathogenesis of Cerebral Small Vessel Disease

Description

Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.

Conditions

Ischemic Stroke, Hypertension, Hyperlipidemias, Diabetes

Study Overview

Study Details

Study overview

Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Condition
Ischemic Stroke
Intervention / Treatment

-

Contacts and Locations

Baltimore

Kennedy Krieger Institute, Baltimore, Maryland, United States, 21205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Clinical or radiographic evidence of ischemic stroke
  • * One vascular risk factor (hypertension, hyperlipidemia, or diabetes)
  • * Evidence of cerebral small vessel disease on MRI
  • * Inability to complete 3 research MRI scans over 1.25 years

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Johns Hopkins University,

Richard Leigh, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2027-03-31