RECRUITING

HEPA, PM2.5, and Cardiometabolic Health

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Conditions

Air PollutionCardiometabolic HealthParticulate matterAir purifierHEPA filter

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.

Official Title

Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals

Quick Facts

Study Start:2023-03-15
Study Completion:2025-04-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05718245

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years to 84 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age between 65 and 84 years old;
  2. * Nonsmoker for at least 1 year;
  3. * History of BMI ≥ 25 kg/m2 in the past based on EMR information;
  4. * Either an English or Spanish speaker;
  5. * Live in the Los Angeles County.
  1. * History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia);
  2. * Currently have active cancer treatment;
  3. * The residential house has already had HEPA filters;
  4. * Participants will move out of the current house in the next 2 years;
  5. * Participants will spend more than one month living outside the primary home;
  6. * Have any health conditions that prohibit collecting health and covariate data and biospecimen;
  7. * The residential houses are not feasible for setting up air purifiers and air pollutants monitors;
  8. * Have high blood glucose from finger stick test (\> 200 mg/dL).

Contacts and Locations

Study Contact

Zhanghua Chen, PhD
CONTACT
323-442-2109
zhanghuc@usc.edu
Junfeng Zhang, PhD
CONTACT
919-681-7782
junfeng.zhang@duke.edu

Principal Investigator

Zhanghua Chen, PhD
PRINCIPAL_INVESTIGATOR
University of Southern California
Junfeng Zhang, PhD
PRINCIPAL_INVESTIGATOR
Duke University

Study Locations (Sites)

Keck School of Medicine, University of Southern California
Los Angeles, California, 90033
United States

Collaborators and Investigators

Sponsor: University of Southern California

  • Zhanghua Chen, PhD, PRINCIPAL_INVESTIGATOR, University of Southern California
  • Junfeng Zhang, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-15
Study Completion Date2025-04-01

Study Record Updates

Study Start Date2023-03-15
Study Completion Date2025-04-01

Terms related to this study

Keywords Provided by Researchers

  • Air pollution
  • Particulate matter
  • Air purifier
  • HEPA filter
  • Cardiometabolic health

Additional Relevant MeSH Terms

  • Air Pollution
  • Cardiometabolic Health