HEPA, PM2.5, and Cardiometabolic Health

Description

The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.

Conditions

Air Pollution, Cardiometabolic Health

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Study Overview

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Study Details

Study overview

The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.

Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals

HEPA, PM2.5, and Cardiometabolic Health

Condition
Air Pollution
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Keck School of Medicine, University of Southern California, Los Angeles, California, United States, 90033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age between 65 and 84 years old;
  • * Nonsmoker for at least 1 year;
  • * History of BMI ≥ 25 kg/m2 in the past based on EMR information;
  • * Either an English or Spanish speaker;
  • * Live in the Los Angeles County.
  • * History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia);
  • * Currently have active cancer treatment;
  • * The residential house has already had HEPA filters;
  • * Participants will move out of the current house in the next 2 years;
  • * Participants will spend more than one month living outside the primary home;
  • * Have any health conditions that prohibit collecting health and covariate data and biospecimen;
  • * The residential houses are not feasible for setting up air purifiers and air pollutants monitors;
  • * Have high blood glucose from finger stick test (\> 200 mg/dL).

Ages Eligible for Study

65 Years to 84 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Southern California,

Zhanghua Chen, PhD, PRINCIPAL_INVESTIGATOR, University of Southern California

Junfeng Zhang, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2025-04-01