RECRUITING

Study of PYX-201 in Solid Tumors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The primary objectives of this study are to determine the recommended dose(s) of PYX-201 for participants with relapsed/refractory (R/R) solid tumors, and to determine the objective response rate (ORR) in participants treated with PYX-201 as a single agent.

Official Title

A First-in-Human, Open-label, Multicenter, Phase 1 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of PYX-201 in Participants With Advanced Solid Tumors

Quick Facts

Study Start:2023-03-14
Study Completion:2027-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05720117

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Loan Vuong
CONTACT
(339) 545 8252
clinicaltrials@pyxisoncology.com

Study Locations (Sites)

HonorHealth Research Institute
Scottsdale, Arizona, 85258
United States
SCRI - HealthOne Denver
Denver, Colorado, 80218
United States
SCRI - Florida Cancer Specialists
Sarasota, Florida, 34232
United States
University of Chicago Medicine
Chicago, Illinois, 60637
United States
Massachusetts General Hospital
Boston, Massachusetts, 02114
United States
Washington University School of Medicine
Saint Louis, Missouri, 63110-1010
United States
Rhode Island Hospital
Providence, Rhode Island, 02903
United States
NEXT Dallas
Dallas, Texas, 75231
United States
NEXT San Antonio
San Antonio, Texas, 78229
United States
NEXT Virginia
Fairfax, Virginia, 22031
United States

Collaborators and Investigators

Sponsor: Pyxis Oncology, Inc

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-14
Study Completion Date2027-05

Study Record Updates

Study Start Date2023-03-14
Study Completion Date2027-05

Terms related to this study

Keywords Provided by Researchers

  • Relapsed/refractory Solid Tumor
  • PYX-201

Additional Relevant MeSH Terms

  • Solid Tumor
  • Advanced Solid Tumor