RECRUITING

Longitudinal Study for Central Nervous System Vasculitis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech impairment, visual loss, dementia, and encephalopathy. The purpose of this study is to establish a research cohort to investigate the disease process, treatments, and patient outcomes in CNSV.

Official Title

Longitudinal Study for Central Nervous System Vasculitis

Quick Facts

Study Start:2023-03-01
Study Completion:2026-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05734404

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. The presence of an acquired and otherwise unexplained neurologic deficit
  2. 2. The presence of either classic angiographic or histopathologic features of angiitis in the CNS
  3. 3. No evidence of systemic vasculitis or any condition that could cause the angiographic or pathologic features
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Carol McAlear
CONTACT
7813214567
cmcalear@upenn.edu

Principal Investigator

Rula Hajj-Ali, MD
PRINCIPAL_INVESTIGATOR
The Cleveland Clinic
Leonard Calabrese, MD
PRINCIPAL_INVESTIGATOR
The Cleveland Clinic
Peter Merkel, MD
PRINCIPAL_INVESTIGATOR
University of Pennsylvania

Study Locations (Sites)

Cleveland Clinic
Cleveland, Ohio, 44195
United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States
Vanderbilt University
Nashville, Tennessee, 37232
United States

Collaborators and Investigators

Sponsor: University of Pennsylvania

  • Rula Hajj-Ali, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic
  • Leonard Calabrese, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic
  • Peter Merkel, MD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-01
Study Completion Date2026-12-31

Study Record Updates

Study Start Date2023-03-01
Study Completion Date2026-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Central Nervous System Vasculitis
  • CNS Vasculitis
  • CNSV
  • Vasculitis