Longitudinal Study for Central Nervous System Vasculitis

Description

Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech impairment, visual loss, dementia, and encephalopathy. The purpose of this study is to establish a research cohort to investigate the disease process, treatments, and patient outcomes in CNSV.

Conditions

Central Nervous System Vasculitis, CNS Vasculitis, CNSV, Vasculitis

Study Overview

Study Details

Study overview

Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech impairment, visual loss, dementia, and encephalopathy. The purpose of this study is to establish a research cohort to investigate the disease process, treatments, and patient outcomes in CNSV.

Longitudinal Study for Central Nervous System Vasculitis

Longitudinal Study for Central Nervous System Vasculitis

Condition
Central Nervous System Vasculitis
Intervention / Treatment

-

Contacts and Locations

Cleveland

Cleveland Clinic, Cleveland, Ohio, United States, 44195

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Nashville

Vanderbilt University, Nashville, Tennessee, United States, 37232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. The presence of an acquired and otherwise unexplained neurologic deficit
  • 2. The presence of either classic angiographic or histopathologic features of angiitis in the CNS
  • 3. No evidence of systemic vasculitis or any condition that could cause the angiographic or pathologic features

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pennsylvania,

Rula Hajj-Ali, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Leonard Calabrese, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Peter Merkel, MD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

2026-12-31