RECRUITING

Modulating Goal-directed Navigation Using Noninvasive Brain Stimulation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Our specific aim is to examine the effects of TMS on spatial processing during goal-directed navigation. In these experiments the investigators will utilize a scalp-recorded brain oscillation called right posterior theta that is believed to index the sensitivity of the parahippocampal cortex to spatial context. Here the investigators will asked whether this electrophysiological signal can be modulated up or down using TMS while participants engage in virtual navigation tasks, and if so, whether it would affect the spatial encoding of rewards and subsequent choices during task performance.

Official Title

Modulating Spatial Processing During Goal-directed Navigation Using Transcranial Magnetic Stimulation

Quick Facts

Study Start:2023-03-24
Study Completion:2025-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05801861

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Be between the ages of 18 and 55 years old.
  2. 2. Not received substance abuse treatment within the previous 30 days.
  3. 3. Be in stable mental and physical health.
  4. 4. If female, test non-pregnant.
  5. 5. No evidence of focal or diffuse brain lesion on MRI.
  6. 6. Be willing to provide informed consent.
  7. 7. Be able to comply with protocol requirements and likely to complete all study procedures.
  1. 1. Contraindication to MRI (e.g., presence of metal in the skull, orbits or intracranial cavity, claustrophobia).
  2. 2. Contraindication to rTMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for \> 15 minutes, implanted electronic device, metal in the head, or pregnancy).
  3. 3. History of autoimmune, endocrine, viral, or vascular disorder affecting the brain.
  4. 4. History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment.
  5. 5. Life time history of mental disorders such as: Bipolar Affective disorder (BPAD), Schizophrenia, Post-traumatic Stress disorder (PTSD) or Dementia or Major Depression.

Contacts and Locations

Study Contact

Travis E Baker, PhD
CONTACT
973-353-5485
travis.e.baker@rutgers.edu
Malte Gueth
CONTACT
973-353-3509
mrg217@newark.rutgers.edu

Principal Investigator

Travis E Baker
PRINCIPAL_INVESTIGATOR
Rutgers University

Study Locations (Sites)

Rutgers University - Newark
Newark, New Jersey, 07102
United States

Collaborators and Investigators

Sponsor: Rutgers, The State University of New Jersey

  • Travis E Baker, PRINCIPAL_INVESTIGATOR, Rutgers University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-24
Study Completion Date2025-08-31

Study Record Updates

Study Start Date2023-03-24
Study Completion Date2025-08-31

Terms related to this study

Keywords Provided by Researchers

  • transcranial magnetic stimulation
  • spatial processing
  • EEG
  • neuroimaging

Additional Relevant MeSH Terms

  • Spatial Navigation