RECRUITING

Cognitive Decline Following Deep Brain Stimulation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.

Official Title

A Neural Basis for Cognitive Decline Following Deep Brain Stimulation

Quick Facts

Study Start:2023-04-01
Study Completion:2025-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05822388

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Subjects above 18 years of age
  2. * Subjects who will undergo DBS surgery as part of their clinical care for PD
  1. * Uncorrected visual or hearing impairments, as indicated by self-report
  2. * Individuals who are pregnant or expect to become pregnant during the course of the study
  3. * Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
  4. * COPD with oxygen dependence
  5. * Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)

Contacts and Locations

Study Contact

Daniel H Lench, PhD
CONTACT
843-792-9115
lenchd@musc.edu
Gonzalo J Revuelta, DO
CONTACT
843-792-7262
revuelta@musc.edu

Principal Investigator

Daniel H Lench, PhD
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Daniel H Lench, PhD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-01
Study Completion Date2025-03-31

Study Record Updates

Study Start Date2023-04-01
Study Completion Date2025-03-31

Terms related to this study

Additional Relevant MeSH Terms

  • Parkinson Disease
  • Movement Disorders