RECRUITING

Testicular Tissue Cryopreservation in the Setting of Gender-Affirming Therapy

Description

The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1. Optimize techniques for processing and cryopreserving testicular tissue. 2. Determine presence and number of germ cells (sperm precursors) in the patients' testicular tissue. 3. Develop next generation cell- and tissue-based therapies for preserving fertility and treating infertility.

Conditions

Gender DysphoriaTransgender
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Related Conditions:

Gender DysphoriaTransgender

Study Overview

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Study Details

Study overview

The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1. Optimize techniques for processing and cryopreserving testicular tissue. 2. Determine presence and number of germ cells (sperm precursors) in the patients' testicular tissue. 3. Develop next generation cell- and tissue-based therapies for preserving fertility and treating infertility.

Testicular Tissue Cryopreservation in the Setting of Gender-Affirming Therapy

Testicular Tissue Cryopreservation in the Setting of Gender-Affirming Therapy

Condition
Gender Dysphoria
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patient with testes over the age of 9
  • * Diagnosed with gender dysphoria; currently on or imminently planning to start gender affirming treatment (hormone blockers or gender-affirming hormones)
  • * Have a clinical referral for fertility preservation from their primary care physician
  • * Unwilling to undergo natal puberty or, for patients who have gone through puberty, unwilling to discontinue hormone suppression and/or hormone replacement therapy.
  • * Patient is 18+ years old
  • * Diagnosed with gender dysphoria
  • * Unwilling to undergo natal puberty, or for patients who have gone through puberty, be unwilling to discontinue hormone suppression and/or sex steroid (estrogen) therapy.
  • * Will be undergoing gender affirming surgery that involves removal of the testes.
  • * Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.
  • * Diagnosed with an underlying medical condition that significantly increases their risk of complications from anesthesia and surgery.

Ages Eligible for Study

9 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pittsburgh,

Kyle Orwig, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh/ University of Pittsburgh Medical Center

Study Record Dates

2029-05