Testicular Tissue Cryopreservation in the Setting of Gender-Affirming Therapy

Description

The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1. Optimize techniques for processing and cryopreserving testicular tissue. 2. Determine presence and number of germ cells (sperm precursors) in the patients' testicular tissue. 3. Develop next generation cell- and tissue-based therapies for preserving fertility and treating infertility.

Conditions

Gender Dysphoria, Transgender

Talk to us

Study Overview

On this page

Study Details

Study overview

The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1. Optimize techniques for processing and cryopreserving testicular tissue. 2. Determine presence and number of germ cells (sperm precursors) in the patients' testicular tissue. 3. Develop next generation cell- and tissue-based therapies for preserving fertility and treating infertility.

Testicular Tissue Cryopreservation in the Setting of Gender-Affirming Therapy

Testicular Tissue Cryopreservation in the Setting of Gender-Affirming Therapy

Condition
Gender Dysphoria
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patient with testes over the age of 9
  • * Diagnosed with gender dysphoria; currently on or imminently planning to start gender affirming treatment (hormone blockers or gender-affirming hormones)
  • * Have a clinical referral for fertility preservation from their primary care physician
  • * Unwilling to undergo natal puberty or, for patients who have gone through puberty, unwilling to discontinue hormone suppression and/or hormone replacement therapy.
  • * Patient is 18+ years old
  • * Diagnosed with gender dysphoria
  • * Unwilling to undergo natal puberty, or for patients who have gone through puberty, be unwilling to discontinue hormone suppression and/or sex steroid (estrogen) therapy.
  • * Will be undergoing gender affirming surgery that involves removal of the testes.
  • * Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.
  • * Diagnosed with an underlying medical condition that significantly increases their risk of complications from anesthesia and surgery.

Ages Eligible for Study

9 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pittsburgh,

Kyle Orwig, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh/ University of Pittsburgh Medical Center

Study Record Dates

2029-05