COMPLETED

Acute Exercise on Brain Insulin Sensitivity

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Dementia is a leading cause of death in the United States among aging adults. Brain insulin resistance has emerged as a pathologic factor affecting memory, executive function as well as systemic glucose control. Regular aerobic exercise decreases Alzheimer's Disease (AD) risk, in part, through changes in brain structure and function. However, there is limited data available on how exercise impacts brain insulin resistance in aging. This study will test the effect of acute exercise on brain insulin sensitivity in middle-aged to older adults. The study will also examine cognition and cardiometabolic health in relation to brain insulin sensitivity.

Official Title

Impact of Acute Exercise on Brain Insulin Sensitivity in Middle-aged to Older Adults

Quick Facts

Study Start:2023-05-11
Study Completion:2025-03-25
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05853913

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male or female \>/=40 and \</=80 years old.
  2. * Has a body mass index \>/=25 and \</=45 kg/m2.
  3. * Physical Activity (\<150 min of moderate/high intensity exercise per week)
  1. * Subjects who have not been weight stable (\>2 kg weight change in past 3 months)
  2. * Subjects who are smokers or who have quit smoking \<1 years ago
  3. * Subjects with abnormal estimated glomerular filtration rate (eGFR).
  4. * Hypertriglyceridemic (\>400 mg/dl) and hypercholesterolemic (\>260 mg/dl) subjects
  5. * Hypertensive (\>160/100 mmHg)
  6. * Subjects with a history of significant metabolic, cardiac, congestive heart failure, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or cancer that in the investigator's opinion would interfere with or alter the outcome measures or impact subject safety.
  7. * Pregnant (as evidenced by positive urine pregnancy test) or nursing women
  8. * Subjects with contraindications to participation in an exercise
  9. * Current Pregnancy
  10. * Currently taking active weight suppression medication (e.g. phentermine, orlistat, lorcaserin, naltrexone-bupropion in combination, liraglutide, benzphetamine, diethylpropion, phendimetrazine)
  11. * Subjects currently taking medications that affect heart rate and rhythm (i.e. Ca++ channel blockers, nitrates, alpha- or beta-blockers).
  12. * Known contraindications for MRI imaging

Contacts and Locations

Principal Investigator

Steven K Malin, PhD
PRINCIPAL_INVESTIGATOR
Rutgers University - New Brunswick

Study Locations (Sites)

Institute for Food, Nutrition, and Health
New Brunswick, New Jersey, 08901
United States
Robert Wood Johnson University Hospital Clinical Research Center
New Brunswick, New Jersey, 08901
United States
Rutgers University Loree Gymnasium
New Brunswick, New Jersey, 08901
United States
Center for Advanced Human Brain Imaging Research
Piscataway, New Jersey, 08854
United States

Collaborators and Investigators

Sponsor: Rutgers, The State University of New Jersey

  • Steven K Malin, PhD, PRINCIPAL_INVESTIGATOR, Rutgers University - New Brunswick

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-05-11
Study Completion Date2025-03-25

Study Record Updates

Study Start Date2023-05-11
Study Completion Date2025-03-25

Terms related to this study

Keywords Provided by Researchers

  • Exercise

Additional Relevant MeSH Terms

  • Aging
  • Obesity
  • Insulin Resistance
  • Cognition
  • Cardiovascular Disease Risk