Acute Exercise on Brain Insulin Sensitivity

Description

Dementia is a leading cause of death in the United States among aging adults. Brain insulin resistance has emerged as a pathologic factor affecting memory, executive function as well as systemic glucose control. Regular aerobic exercise decreases Alzheimer's Disease (AD) risk, in part, through changes in brain structure and function. However, there is limited data available on how exercise impacts brain insulin resistance in aging. This study will test the effect of acute exercise on brain insulin sensitivity in middle-aged to older adults. The study will also examine cognition and cardiometabolic health in relation to brain insulin sensitivity.

Conditions

Aging, Obesity, Insulin Resistance, Cognition, Cardiovascular Disease Risk

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Study Overview

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Study Details

Study overview

Dementia is a leading cause of death in the United States among aging adults. Brain insulin resistance has emerged as a pathologic factor affecting memory, executive function as well as systemic glucose control. Regular aerobic exercise decreases Alzheimer's Disease (AD) risk, in part, through changes in brain structure and function. However, there is limited data available on how exercise impacts brain insulin resistance in aging. This study will test the effect of acute exercise on brain insulin sensitivity in middle-aged to older adults. The study will also examine cognition and cardiometabolic health in relation to brain insulin sensitivity.

Impact of Acute Exercise on Brain Insulin Sensitivity in Middle-aged to Older Adults

Acute Exercise on Brain Insulin Sensitivity

Condition
Aging
Intervention / Treatment

-

Contacts and Locations

New Brunswick

Institute for Food, Nutrition, and Health, New Brunswick, New Jersey, United States, 08901

New Brunswick

Robert Wood Johnson University Hospital Clinical Research Center, New Brunswick, New Jersey, United States, 08901

New Brunswick

Rutgers University Loree Gymnasium, New Brunswick, New Jersey, United States, 08901

Piscataway

Center for Advanced Human Brain Imaging Research, Piscataway, New Jersey, United States, 08854

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or female \>40 and \<80 years old.
  • * Has a body mass index \>25 and \<45 kg/m2.
  • * Physical Activity (\<150 min of moderate/high intensity exercise per week)
  • * Subjects who have not been weight stable (\>2 kg weight change in past 3 months)
  • * Subjects who are smokers or who have quit smoking \<1 years ago
  • * Subjects with abnormal estimated glomerular filtration rate (eGFR).
  • * Hypertriglyceridemic (\>400 mg/dl) and hypercholesterolemic (\>260 mg/dl) subjects
  • * Hypertensive (\>160/100 mmHg)
  • * Subjects with a history of significant metabolic, cardiac, congestive heart failure, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or cancer that in the investigator's opinion would interfere with or alter the outcome measures or impact subject safety.
  • * Pregnant (as evidenced by positive urine pregnancy test) or nursing women
  • * Subjects with contraindications to participation in an exercise
  • * Current Pregnancy
  • * Currently taking active weight suppression medication (e.g. phentermine, orlistat, lorcaserin, naltrexone-bupropion in combination, liraglutide, benzphetamine, diethylpropion, phendimetrazine)
  • * Subjects currently taking medications that affect heart rate and rhythm (i.e. Ca++ channel blockers, nitrates, alpha- or beta-blockers).
  • * Known contraindications for MRI imaging

Ages Eligible for Study

40 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Rutgers, The State University of New Jersey,

Steven K Malin, PhD, PRINCIPAL_INVESTIGATOR, Rutgers University - New Brunswick

Study Record Dates

2025-12-30