RECRUITING

Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.

Official Title

Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

Quick Facts

Study Start:2024-06-03
Study Completion:2028-09-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05880108

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. U.S. Veteran
  2. 2. No Post-COVID symptoms or at least one Post-COVID symptom lasting \>4 weeks
  3. 3. Body Mass Index: 19-25 or 30-40 kg/m2
  4. 4. Postmenopausal status for women
  1. 1. Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments
  2. 2. Active inflammatory, COVID-19, autoimmune, infectious, hepatic (LFTs \> 2.5 x WNL), renal (eGFR\<45), gastrointestinal, malignant, and psychiatric disease
  3. 3. Uncontrolled diabetes (HbA1c \>10% or the current use of insulin)
  4. 4. Weight change within the past month of \>5 kg
  5. 5. History of keloid formation
  6. 6. Self-reported alcohol or drug abuse
  7. 7. Anti-coagulant medication usage

Contacts and Locations

Study Contact

Monica C Serra, PhD
CONTACT
(814) 332-9939
Monica.Serra@va.gov
Tim Calderon, MS
CONTACT
(210) 617-5300
tim.calderon@va.gov

Principal Investigator

Monica C Serra, PhD
PRINCIPAL_INVESTIGATOR
South Texas Health Care System, San Antonio, TX

Study Locations (Sites)

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Maryland, 21201
United States
South Texas Health Care System, San Antonio, TX
San Antonio, Texas, 78229-4404
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Monica C Serra, PhD, PRINCIPAL_INVESTIGATOR, South Texas Health Care System, San Antonio, TX

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-03
Study Completion Date2028-09-30

Study Record Updates

Study Start Date2024-06-03
Study Completion Date2028-09-30

Terms related to this study

Keywords Provided by Researchers

  • COVID-19
  • Obesity
  • Senescence
  • Weight Loss
  • Exercise

Additional Relevant MeSH Terms

  • Post-COVID Conditions
  • Obesity