Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

Description

The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.

Conditions

Post-COVID Conditions, Obesity

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Study Overview

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Study Details

Study overview

The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.

Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation

Condition
Post-COVID Conditions
Intervention / Treatment

-

Contacts and Locations

Baltimore

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland, United States, 21201

San Antonio

South Texas Health Care System, San Antonio, TX, San Antonio, Texas, United States, 78229-4404

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. U.S. Veteran
  • 2. No Post-COVID symptoms or at least one Post-COVID symptom lasting \>4 weeks
  • 3. Body Mass Index: 19-25 or 30-40 kg/m2
  • 4. Postmenopausal status for women
  • 1. Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments
  • 2. Active inflammatory, COVID-19, autoimmune, infectious, hepatic (LFTs \> 2.5 x WNL), renal (eGFR\<45), gastrointestinal, malignant, and psychiatric disease
  • 3. Uncontrolled diabetes (HbA1c \>10% or the current use of insulin)
  • 4. Weight change within the past month of \>5 kg
  • 5. History of keloid formation
  • 6. Self-reported alcohol or drug abuse
  • 7. Anti-coagulant medication usage

Ages Eligible for Study

55 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

VA Office of Research and Development,

Monica C Serra, PhD, PRINCIPAL_INVESTIGATOR, South Texas Health Care System, San Antonio, TX

Study Record Dates

2028-09-30