RECRUITING

Aspirin for Postpartum Patients With Preeclampsia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth. We hypothesize that taking aspirin for the first week after giving birth will enhance recovery from preeclampsia by decreasing the levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to be a main contributor to the development of preeclampsia, and speeding up return to a normal blood pressure.

Official Title

Acetylsalicylic Acid for Postpartum Preeclampsia: A Pilot Randomized Trial

Quick Facts

Study Start:2023-07-26
Study Completion:2024-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05924971

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Preeclampsia with severe features diagnosed during delivery admission, as defined by ACOG criteria.
  2. * Pre- and postnatal care provided by the Long Beach Memorial Ob/Gyn resident or Maternal-Fetal Medicine clinic.
  1. * Patient age \<18 years old
  2. * Non-English or Non-Spanish speaking
  3. * Chronic hypertension diagnosed before 20 weeks' gestation
  4. * Known allergy, prior adverse reaction, or any medical condition in which aspirin is contraindicated (nasal polyps, gastric or duodenal ulcers, history of gastrointestinal bleeding, severe hepatic dysfunction)
  5. * Aspirin prescribed postpartum for any other medical condition
  6. * Bleeding disorder
  7. * Breastfeeding an infant with thrombocytopenia

Contacts and Locations

Study Contact

Megan C Oakes, MD MSCI
CONTACT
562-997-8510
moakes2@memorialcare.org
Ashten B Waks, MD MSPH
CONTACT
562-997-8510
awaks@memorialcare.org

Principal Investigator

Megan C Oakes, MD MSCI
PRINCIPAL_INVESTIGATOR
Miller Children's and Women's Hospital, Long Beach/ MemorialCare Medical Center

Study Locations (Sites)

Miller Children's and Women's Hospital, Long Beach/MemorialCare Long Beach
Long Beach, California, 90740
United States

Collaborators and Investigators

Sponsor: MemorialCare Health System

  • Megan C Oakes, MD MSCI, PRINCIPAL_INVESTIGATOR, Miller Children's and Women's Hospital, Long Beach/ MemorialCare Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-26
Study Completion Date2024-09

Study Record Updates

Study Start Date2023-07-26
Study Completion Date2024-09

Terms related to this study

Keywords Provided by Researchers

  • Preeclampsia
  • Postpartum
  • Aspirin
  • sFlt-1

Additional Relevant MeSH Terms

  • Preeclampsia Postpartum