Aspirin for Postpartum Patients With Preeclampsia

Description

The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth. We hypothesize that taking aspirin for the first week after giving birth will enhance recovery from preeclampsia by decreasing the levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to be a main contributor to the development of preeclampsia, and speeding up return to a normal blood pressure.

Conditions

Preeclampsia Postpartum

Study Overview

Study Details

Study overview

The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth. We hypothesize that taking aspirin for the first week after giving birth will enhance recovery from preeclampsia by decreasing the levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to be a main contributor to the development of preeclampsia, and speeding up return to a normal blood pressure.

Acetylsalicylic Acid for Postpartum Preeclampsia: A Pilot Randomized Trial

Aspirin for Postpartum Patients With Preeclampsia

Condition
Preeclampsia Postpartum
Intervention / Treatment

-

Contacts and Locations

Long Beach

Miller Children's and Women's Hospital, Long Beach/MemorialCare Long Beach, Long Beach, California, United States, 90740

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Preeclampsia with severe features diagnosed during delivery admission, as defined by ACOG criteria.
  • * Pre- and postnatal care provided by the Long Beach Memorial Ob/Gyn resident or Maternal-Fetal Medicine clinic.
  • * Patient age \<18 years old
  • * Non-English or Non-Spanish speaking
  • * Chronic hypertension diagnosed before 20 weeks' gestation
  • * Known allergy, prior adverse reaction, or any medical condition in which aspirin is contraindicated (nasal polyps, gastric or duodenal ulcers, history of gastrointestinal bleeding, severe hepatic dysfunction)
  • * Aspirin prescribed postpartum for any other medical condition
  • * Bleeding disorder
  • * Breastfeeding an infant with thrombocytopenia

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

MemorialCare Health System,

Megan C Oakes, MD MSCI, PRINCIPAL_INVESTIGATOR, Miller Children's and Women's Hospital, Long Beach/ MemorialCare Medical Center

Study Record Dates

2024-09