RECRUITING

Remimazolam for Cataract Surgery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to assess any post operative cognitive changes following benzodiazepine administration during cataract surgery. The investigators will compare effects of Midazolam vs. Remimazolam on cognition at the time of discharge from the post operative care unit and the next day following surgery. Cognitive changes will be assessed by administration of Montreal Cognitive Assessment (MoCA). Participants will: 1. Complete MoCA testing prior to surgery 2. Randomize in either Midazolam or study drug Remimazolam 3. Complete MoCA testing after surgery at the time of discharge in the post anesthesia care unit and the next day of surgery at the time of post operative surgical visit. 4. Complete Patient Satisfaction Survey at the time of discharge from the Post Anesthesia Care Unit (PACU)

Official Title

Comparison of Remimazolam vs. Midazolam for Sedation During Cataract Surgery

Quick Facts

Study Start:2025-03-10
Study Completion:2026-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05980117

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Adult patients age \> 65 years undergoing first eye cataract surgery under local topical anesthesia at the University of California, Los Angeles (UCLA).
  2. 2. Both male and female patients
  3. 3. American Society of Anesthesiologists Class 2, 3, and 4.
  1. 1. Patients who are unable to consent for the study
  2. 2. Patients who are unable to cooperate with the cognitive assessment such as patients with significant visual, auditory, language or other impairment.
  3. 3. Patients who are unable to understand simple English commands.
  4. 4. Patients who do not wish to have benzodiazepine medication during surgery
  5. 5. Patients with a history of severe hypersensitivity reaction to dextran 40 or products containing dextran 40.
  6. 6. Patients with chronic pain on opiates.
  7. 7. Patients with a history of drug, alcohol abuse/dependence.
  8. 8. Patients with BMI \> 40.
  9. 9. Patients with obstructive sleep apnea (moderate to severe).

Contacts and Locations

Study Contact

Zhuang T Fang, MD
CONTACT
310-267-8946
ZFang@mednet.ucla.edu
Stephanie-Dee Sarovich, BS
CONTACT
424-832-6842
ssarovich@mednet.ucla.edu

Principal Investigator

Zhuang Fang, MD
PRINCIPAL_INVESTIGATOR
University of California, Los Angeles

Study Locations (Sites)

Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine
Los Angeles, California, 90095
United States

Collaborators and Investigators

Sponsor: University of California, Los Angeles

  • Zhuang Fang, MD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-10
Study Completion Date2026-01

Study Record Updates

Study Start Date2025-03-10
Study Completion Date2026-01

Terms related to this study

Keywords Provided by Researchers

  • Midazolam
  • Remimazolam
  • Outcomes

Additional Relevant MeSH Terms

  • Cataract Surgery
  • Cognitive Impairment