Remimazolam for Cataract Surgery

Description

The goal of this study is to assess any post operative cognitive changes following benzodiazepine administration during cataract surgery. The investigators will compare effects of Midazolam vs. Remimazolam on cognition at the time of discharge from the post operative care unit and the next day following surgery. Cognitive changes will be assessed by administration of Montreal Cognitive Assessment (MoCA). Participants will: 1. Complete MoCA testing prior to surgery 2. Randomize in either Midazolam or study drug Remimazolam 3. Complete MoCA testing after surgery at the time of discharge in the post anesthesia care unit and the next day of surgery at the time of post operative surgical visit. 4. Complete Patient Satisfaction Survey at the time of discharge from the Post Anesthesia Care Unit (PACU)

Conditions

Cataract Surgery, Cognitive Impairment

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Study Overview

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Study Details

Study overview

The goal of this study is to assess any post operative cognitive changes following benzodiazepine administration during cataract surgery. The investigators will compare effects of Midazolam vs. Remimazolam on cognition at the time of discharge from the post operative care unit and the next day following surgery. Cognitive changes will be assessed by administration of Montreal Cognitive Assessment (MoCA). Participants will: 1. Complete MoCA testing prior to surgery 2. Randomize in either Midazolam or study drug Remimazolam 3. Complete MoCA testing after surgery at the time of discharge in the post anesthesia care unit and the next day of surgery at the time of post operative surgical visit. 4. Complete Patient Satisfaction Survey at the time of discharge from the Post Anesthesia Care Unit (PACU)

Comparison of Remimazolam vs. Midazolam for Sedation During Cataract Surgery

Remimazolam for Cataract Surgery

Condition
Cataract Surgery
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles, California, United States, 90095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Adult patients age \> 65 years undergoing first eye cataract surgery under local topical anesthesia at the University of California, Los Angeles (UCLA).
  • 2. Both male and female patients
  • 3. American Society of Anesthesiologists Class 2, 3, and 4.
  • 1. Patients who are unable to consent for the study
  • 2. Patients who are unable to cooperate with the cognitive assessment such as patients with significant visual, auditory, language or other impairment.
  • 3. Patients who are unable to understand simple English commands.
  • 4. Patients who do not wish to have benzodiazepine medication during surgery
  • 5. Patients with a history of severe hypersensitivity reaction to dextran 40 or products containing dextran 40.
  • 6. Patients with chronic pain on opiates.
  • 7. Patients with a history of drug, alcohol abuse/dependence.
  • 8. Patients with BMI \> 40.
  • 9. Patients with obstructive sleep apnea (moderate to severe).

Ages Eligible for Study

65 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Los Angeles,

Zhuang Fang, MD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

2026-01