RECRUITING

NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis

Conditions

Thumb Osteoarthritis Injection Steroid NSAID Thumb Arthritis CMC Arthritis

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The Researchers are trying to compare two different types of intraarticular injections (injection in the joint) for treating the symptoms of moderate to advanced basilar thumb arthritis. One injection is ketorolac (an NSAID) and the other is triamcinolone (a corticosteroid).

Official Title

NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis: a Randomized, Controlled Trial

Quick Facts

Study Start:2023-07-28

Study Completion:2025-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05992883

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Adults \>40 years of age * Pain at the thumb base brought on by direct pressure (grind test) and with movement * Pain resistant to previous conservative management (including over the counter medications (ibuprofen/acetaminophen), icing, splinting/braces, or topical analgesics) * Radiological observation indicative of arthritis based on the Eaton-Littler classification system (stages 1 through 4) * Patient understands the protocol and signed the informed consent * Patient is covered by health insurance	* • Known allergy to either of the treatment products * Patient's analgesic treatment regimen or other modalities of managing symptoms/pain associated with their hand pathology was modified within four weeks before trial inclusion * Symptomatic Scaphoid-trapezial arthritis present * Localized or systemic infection * Previous thumb surgery on study thumb * Previous thumb injury on study thumb * Patient with inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis) * Severe and/or uncontrolled hypertension * De Quervain tendinopathy present * History of injection to the trapeziometacarpal joint on study thumb within the previous 6 weeks * Uncontrolled diabetes * Pregnant or lactating females. Female participants of childbearing potential must have a negative pregnancy test before the injection. Women without childbearing potential (ie., surgically sterile with hysterectomy and/or bilateral oophorectomy and/or bilateral salpingectomy OR ≥ 12 months of amenorrhea and at least 50 years of age) are eligible to participate without completing a pregnancy test. * Immunodeficient patients * Patients that are currently using nicotine products, or who have quit in the last 12 months * Patients under guardianship, curatorship, or are otherwise not self-sufficient * Patients participating in another clinical research trial which interferes with this study protocol or outcomes * Patients unable to follow the protocol in the investigators' judgement.

Inclusion Criteria

Exclusion Criteria

* Adults \>40 years of age
* Pain at the thumb base brought on by direct pressure (grind test) and with movement
* Pain resistant to previous conservative management (including over the counter medications (ibuprofen/acetaminophen), icing, splinting/braces, or topical analgesics)
* Radiological observation indicative of arthritis based on the Eaton-Littler classification system (stages 1 through 4)
* Patient understands the protocol and signed the informed consent
* Patient is covered by health insurance

* • Known allergy to either of the treatment products
* Patient's analgesic treatment regimen or other modalities of managing symptoms/pain associated with their hand pathology was modified within four weeks before trial inclusion
* Symptomatic Scaphoid-trapezial arthritis present
* Localized or systemic infection
* Previous thumb surgery on study thumb
* Previous thumb injury on study thumb
* Patient with inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis)
* Severe and/or uncontrolled hypertension
* De Quervain tendinopathy present
* History of injection to the trapeziometacarpal joint on study thumb within the previous 6 weeks
* Uncontrolled diabetes
* Pregnant or lactating females. Female participants of childbearing potential must have a negative pregnancy test before the injection. Women without childbearing potential (ie., surgically sterile with hysterectomy and/or bilateral oophorectomy and/or bilateral salpingectomy OR ≥ 12 months of amenorrhea and at least 50 years of age) are eligible to participate without completing a pregnancy test.
* Immunodeficient patients
* Patients that are currently using nicotine products, or who have quit in the last 12 months
* Patients under guardianship, curatorship, or are otherwise not self-sufficient
* Patients participating in another clinical research trial which interferes with this study protocol or outcomes
* Patients unable to follow the protocol in the investigators' judgement.

Contacts and Locations

Study Contact

Lindsey Hobbs

CONTACT

5072939765

hobbs.lindsey@mayo.edu

Principal Investigator

Marco Rizzo, MD

PRINCIPAL_INVESTIGATOR

Mayo Clinic

Study Locations (Sites)

Mayo Clinic

Rochester, Minnesota, 55905

United States

Collaborators and Investigators

Sponsor: Mayo Clinic

Marco Rizzo, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-28

Study Completion Date2025-12-31

Study Record Updates

Study Start Date2023-07-28

Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

Injection
Steroid
NSAID
Thumb Arthritis
CMC Arthritis

Additional Relevant MeSH Terms

Thumb Osteoarthritis