ACTIVE_NOT_RECRUITING

The Effect of Intermittent Fasting on Brain Health

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through activation of SIRT1-dependent vasoprotective pathways.

Official Title

Time Restricted Eating for Prevention of Age-related Vascular Cognitive Decline in Older Adults

Quick Facts

Study Start:2024-05-13

Study Completion:2026-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06019195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 80 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Age ≥55 and ≤80 years of age * Adequate hearing and visual acuity to participate in the examinations * Ability to read and write in English * Competence to provide informed consent. * Mini Montreal Cognitive Assessment ≥12 * Mini Nutritional Assessment ≥12	* Vision or hearing impairment that would impair the ability to complete study assessments * Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer * Cerebrovascular accident other than TIA within 60 days prior to Visit 0 * Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse * Diabetics prescribed sulfonylureas, meglitinides, and insulin * Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol

Inclusion Criteria

Exclusion Criteria

* Age ≥55 and ≤80 years of age
* Adequate hearing and visual acuity to participate in the examinations
* Ability to read and write in English
* Competence to provide informed consent.
* Mini Montreal Cognitive Assessment ≥12
* Mini Nutritional Assessment ≥12

* Vision or hearing impairment that would impair the ability to complete study assessments
* Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
* Cerebrovascular accident other than TIA within 60 days prior to Visit 0
* Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
* Diabetics prescribed sulfonylureas, meglitinides, and insulin
* Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol

Contacts and Locations

Principal Investigator

Andriy Yabluchanskiy, MD, PhD

PRINCIPAL_INVESTIGATOR

University of Oklahoma

Study Locations (Sites)

Translational GeroScience Laboratory

Oklahoma City, Oklahoma, 73117

United States

Collaborators and Investigators

Sponsor: University of Oklahoma

Andriy Yabluchanskiy, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Oklahoma

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-05-13

Study Completion Date2026-12-31

Study Record Updates

Study Start Date2024-05-13

Study Completion Date2026-12-31

Terms related to this study

Keywords Provided by Researchers

Intermittent Fasting
Aging

Additional Relevant MeSH Terms

Intermittent Fasting
Aging