The Effect of Intermittent Fasting on Brain Health

Description

The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through activation of SIRT1-dependent vasoprotective pathways.

Conditions

Intermittent Fasting, Aging

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Study Overview

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Study Details

Study overview

The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through activation of SIRT1-dependent vasoprotective pathways.

Time Restricted Eating for Prevention of Age-related Vascular Cognitive Decline in Older Adults

The Effect of Intermittent Fasting on Brain Health

Condition
Intermittent Fasting
Intervention / Treatment

-

Contacts and Locations

Oklahoma City

Translational GeroScience Laboratory, Oklahoma City, Oklahoma, United States, 73117

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥55 and ≤80 years of age
  • * Adequate hearing and visual acuity to participate in the examinations
  • * Ability to read and write in English
  • * Competence to provide informed consent.
  • * Mini Montreal Cognitive Assessment ≥12
  • * Mini Nutritional Assessment ≥12
  • * Vision or hearing impairment that would impair the ability to complete study assessments
  • * Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
  • * Cerebrovascular accident other than TIA within 60 days prior to Visit 0
  • * Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
  • * Diabetics prescribed sulfonylureas, meglitinides, and insulin
  • * Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol

Ages Eligible for Study

55 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Oklahoma,

Andriy Yabluchanskiy, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Oklahoma

Study Record Dates

2026-07-31