RECRUITING

Blood Flow Regulation and Neuromuscular Function Post-Stroke

Description

The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.

Conditions

Study Overview

Study Details

Study overview

The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.

Blood Flow Regulation and Neuromuscular Function Post-Stroke

Blood Flow Regulation and Neuromuscular Function Post-Stroke

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Milwaukee

Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 53226

Milwaukee

Marquette University, Milwaukee, Wisconsin, United States, 53233

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Be between 18-85 years of age
  • * Able to give informed consent
  • * ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke
  • * English speaking
  • * History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg)
  • * Chronic pain syndrome
  • * Low back or hip pain that interferes with lower extremity motor testing
  • * History of head trauma
  • * Comorbid neurological disorder
  • * Peripheral vascular disease
  • * Myocardial infarction in the previous year
  • * Inability to follow 2 step commands
  • * Condition where fatiguing contractions or resisted leg contractions are contraindicated
  • * Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg
  • * Pregnancy or breastfeeding.

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Medical College of Wisconsin,

Study Record Dates

2028-06-30