RECRUITING

Blood Flow Regulation and Neuromuscular Function Post-Stroke

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.

Official Title

Blood Flow Regulation and Neuromuscular Function Post-Stroke

Quick Facts

Study Start:2024-01-11
Study Completion:2028-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06027294

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Be between 18-85 years of age
  2. * Able to give informed consent
  3. * ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke
  4. * English speaking
  1. * History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg)
  2. * Chronic pain syndrome
  3. * Low back or hip pain that interferes with lower extremity motor testing
  4. * History of head trauma
  5. * Comorbid neurological disorder
  6. * Peripheral vascular disease
  7. * Myocardial infarction in the previous year
  8. * Inability to follow 2 step commands
  9. * Condition where fatiguing contractions or resisted leg contractions are contraindicated
  10. * Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg
  11. * Pregnancy or breastfeeding.

Contacts and Locations

Study Contact

Matthew Durand, Ph.D.
CONTACT
4149555619
mdurand@mcw.edu
Jennifer Nguyen, BS
CONTACT
jnguyen@mcw.edu

Study Locations (Sites)

Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
United States
Marquette University
Milwaukee, Wisconsin, 53233
United States

Collaborators and Investigators

Sponsor: Medical College of Wisconsin

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-11
Study Completion Date2028-06-30

Study Record Updates

Study Start Date2024-01-11
Study Completion Date2028-06-30

Terms related to this study

Additional Relevant MeSH Terms

  • Stroke