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Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea

Description

The purpose of this study is to evaluate how supplementation will alter the skin and the gut barrier and inflammation in those with rosacea.

Study Overview

Study Details

Study overview

The purpose of this study is to evaluate how supplementation will alter the skin and the gut barrier and inflammation in those with rosacea.

The Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea

Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea

Condition
Rosacea
Intervention / Treatment

-

Contacts and Locations

Sacramento

Integrative Skin and Research, Sacramento, California, United States, 95815

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Males and females 30 to 70 years of age
  • * The presence of mild to moderate rosacea (erythematotelangiectatic or papulopustular)
  • * High sensitivity C-reactive protein (hs-CRP) that is greater than or equal to 1.0 mg/L
  • * The presence of severe rosacea as noted by the investigator global assessment.
  • * Those who are unwilling to discontinue oral supplementation, or supplement ingredients found in the study's oral product 1 month prior to enrollment.
  • * Discontinuation of oral L-glutamine or L-glutamine containing supplement 1 month prior to enrollment
  • * Those who are unwilling to discontinue topical benzoyl peroxide or retinoids for 2 weeks prior to enrollment.
  • * Those who are unwilling to keep their facial regimen the same throughout the study.
  • * Individuals who have been on an oral antibiotic within the previous one month.
  • * Individuals who are pregnant or breastfeeding.
  • * Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study.
  • * Individuals on oral contraceptive pills or progesterone or estrogen containing therapies.
  • * Use of isotretinoin within the three months prior to enrollment.
  • * Individuals on finasteride or dutasteride
  • * Current tobacco smoker, smoker within the past year, or greater than 5 pack-year tobacco smoking history.

Ages Eligible for Study

30 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Integrative Skin Science and Research,

Study Record Dates

2024-12-31