RECRUITING

Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea

Conditions

Rosacea Systemic Inflammation L-Histidine Antioxidants

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to evaluate how supplementation will alter the skin and the gut barrier and inflammation in those with rosacea.

Official Title

The Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea

Quick Facts

Study Start:2023-11-22

Study Completion:2024-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06072066

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:30 Years to 70 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Males and females 30 to 70 years of age * The presence of mild to moderate rosacea (erythematotelangiectatic or papulopustular) * High sensitivity C-reactive protein (hs-CRP) that is greater than or equal to 1.0 mg/L	* The presence of severe rosacea as noted by the investigator global assessment. * Those who are unwilling to discontinue oral supplementation, or supplement ingredients found in the study's oral product 1 month prior to enrollment. * Discontinuation of oral L-glutamine or L-glutamine containing supplement 1 month prior to enrollment * Those who are unwilling to discontinue topical benzoyl peroxide or retinoids for 2 weeks prior to enrollment. * Those who are unwilling to keep their facial regimen the same throughout the study. * Individuals who have been on an oral antibiotic within the previous one month. * Individuals who are pregnant or breastfeeding. * Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study. * Individuals on oral contraceptive pills or progesterone or estrogen containing therapies. * Use of isotretinoin within the three months prior to enrollment. * Individuals on finasteride or dutasteride * Current tobacco smoker, smoker within the past year, or greater than 5 pack-year tobacco smoking history.

Inclusion Criteria

Exclusion Criteria

* Males and females 30 to 70 years of age
* The presence of mild to moderate rosacea (erythematotelangiectatic or papulopustular)
* High sensitivity C-reactive protein (hs-CRP) that is greater than or equal to 1.0 mg/L

* The presence of severe rosacea as noted by the investigator global assessment.
* Those who are unwilling to discontinue oral supplementation, or supplement ingredients found in the study's oral product 1 month prior to enrollment.
* Discontinuation of oral L-glutamine or L-glutamine containing supplement 1 month prior to enrollment
* Those who are unwilling to discontinue topical benzoyl peroxide or retinoids for 2 weeks prior to enrollment.
* Those who are unwilling to keep their facial regimen the same throughout the study.
* Individuals who have been on an oral antibiotic within the previous one month.
* Individuals who are pregnant or breastfeeding.
* Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study.
* Individuals on oral contraceptive pills or progesterone or estrogen containing therapies.
* Use of isotretinoin within the three months prior to enrollment.
* Individuals on finasteride or dutasteride
* Current tobacco smoker, smoker within the past year, or greater than 5 pack-year tobacco smoking history.

Contacts and Locations

Study Contact

Caitlin Egli

CONTACT

916-750-2463

research@integrativeskinresearch.com

Milred Min

CONTACT

milred@integrativeskinresearch.com

Study Locations (Sites)

Integrative Skin and Research

Sacramento, California, 95815

United States

Collaborators and Investigators

Sponsor: Integrative Skin Science and Research

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-11-22

Study Completion Date2024-12-31

Study Record Updates

Study Start Date2023-11-22

Study Completion Date2024-12-31

Terms related to this study

Keywords Provided by Researchers

Rosacea
L-Histidine
Antioxidants

Additional Relevant MeSH Terms

Rosacea
Systemic Inflammation